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In addition, six sporadic ATDAC patients with Graves' disease were investigated. Whole exome sequencing analysis of affected and unaffected family members was performed to identify genetic susceptibility variants for ATDAC, followed by functional characterization of primary granulocytes from patients and unrelated healthy controls. Whole exome sequencing, cosegregation analysis, and stringent selection criteria of candidate gene variants identified <jats:italic>NOX3<\/jats:italic> as a genetic factor related to ATDAC. Functional studies revealed increased apoptosis of methimazole\u2010treated granulocytes from patients carrying <jats:italic>NOX3<\/jats:italic> variants. In conclusion, genetic variants in <jats:italic>NOX3<\/jats:italic> may confer susceptibility to antithyroid drug\u2010induced apoptosis of granulocytes. These findings contribute to the understanding of the mechanisms underlying ATDAC.<\/jats:p>","DOI":"10.1002\/cpt.733","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T23:36:53Z","timestamp":1494373013000},"page":"1017-1024","source":"Crossref","is-referenced-by-count":13,"title":["Rare NOX3 Variants Confer Susceptibility to Agranulocytosis During Thyrostatic Treatment of Graves' Disease"],"prefix":"10.1111","volume":"102","author":[{"given":"TS","family":"Plantinga","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology, Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Arts","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Radboud University Medical Center Nijmegen The 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