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Preoperatively, we studied heat and cold pain sensitivities and anxiety scores. Postoperatively, rest and motion pain intensities were measured and intravenous oxycodone was administered until satisfactory analgesia. At this point, the mean oxycodone concentration (variation coefficient) was 33.3 ng\/mL (66%) and it was 21.7 ng\/mL (69%) when the patient requested oxycodone again. At both time points, the concentrations varied &gt;100\u2010fold between individuals. The analgesic oxycodone concentration was increased by 21.3% per motion pain intensity score on a 0\u201310 scale and by 22.3% if axillary clearance was performed instead of sentinel node biopsy (<jats:italic>P<\/jats:italic> &lt; 0.001). Forty\u2010seven women who were older and less anxious than others (<jats:italic>P<\/jats:italic> &lt; 0.01) required no oxycodone. Anxiety, age, chronic pain, or preoperative pain sensitivity were not independently associated with the analgesic oxycodone concentration. <jats:italic>CYP2D6<\/jats:italic> and <jats:italic>CYP3A<\/jats:italic> genotypes did not affect analgesic concentration or duration of analgesia.<\/jats:p>","DOI":"10.1002\/cpt.771","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T08:00:47Z","timestamp":1498204847000},"page":"653-662","source":"Crossref","is-referenced-by-count":26,"title":["Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer\u2014Which Factors Matter?"],"prefix":"10.1111","volume":"103","author":[{"given":"Kristiina","family":"Cajanus","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Neuvonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki and Helsinki University Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Koskela","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki and Helsinki University Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari A.","family":"Kaunisto","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM) University of Helsinki  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti J.","family":"Neuvonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki and Helsinki University Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Niemi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology University of Helsinki and Helsinki University Hospital  Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Kalso","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32832bc818"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1991.tb03364.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199710000-00017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181aae87a"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.470105.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer395"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586140-000000000-00000"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31824f19b8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181ebdaf9"},{"key":"e_1_2_10_11_1","first-page":"53","article-title":"Predictors of patient reported pain after lower extremity nonunion surgery: the nicotine effect","volume":"36","author":"Christiano A.V.","year":"2016","journal-title":"Iowa Orthop. 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