{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:06:23Z","timestamp":1781085983126,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysian Ministry of Higher Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>We evaluated the contribution of patient\u2010specific clinical and genetic factors to statin\u2010related muscle toxicity (SRM) without a significant creatine kinase elevation (125 cases related to simvastatin or atorvastatin and 481 controls). The association between 12 single nucleotide polymorphisms (SNPs) in nine candidate genes and clinical factors with SRM was evaluated. Of the 12 SNPs genotyped, only rs4149056 in <jats:italic>SLCO1B1<\/jats:italic> was associated with SRM in univariate analysis (with any statin, odd ratio (OR)\u2009=\u20091.73, 95% confidence interval (CI)\u2009=\u20091.14\u20132.62, <jats:italic>P<\/jats:italic>\u2009=\u20090.010) and this association was influenced by sex (<jats:italic>P<\/jats:italic>\u2009=\u20090.006) and BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). In multivariate and binary logistic regression analyses, <jats:italic>SLCO1B1<\/jats:italic> rs4149056 genotype (OR\u2009=\u20091.66, 95% CI: 1.08\u20132.54, <jats:italic>P<\/jats:italic>\u2009=\u20090.014) and sex (OR\u2009=\u20091.72, 95% CI\u2009=\u20091.15\u20132.59, <jats:italic>P<\/jats:italic>\u2009=\u20090.006) were independently associated with muscle toxicity related to statin treatment. Patient\u2010specific genetic and clinical factors associated with increased systemic exposure to statins are implicated in the full spectrum of SRM, including myalgia in addition to severe myopathy.<\/jats:p>","DOI":"10.1002\/cpt.887","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T08:38:44Z","timestamp":1506069524000},"page":"178-187","source":"Crossref","is-referenced-by-count":26,"title":["Genetic and Clinical Factors Are Associated With Statin\u2010Related Myotoxicity of Moderate Severity: A Case\u2013Control Study"],"prefix":"10.1111","volume":"104","author":[{"given":"Nur Salwani","family":"Bakar","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"Neely","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Newcastle upon Tyne Hospitals Foundation Trust Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Avery","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Brown","sequence":"additional","affiliation":[{"name":"Institute for Cell and Molecular Biosciences Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann K.","family":"Daly","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Kamali","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht295"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv043"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-7-201304020-00004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1335"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31357-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.08.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3608"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2014.121"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801936"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1287"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2010.02.026"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.12.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.12.11"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000032466.44170.44"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.57"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12360"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000230416.82349.90"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.053"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.255"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.92"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2013.161"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001268"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893007"},{"key":"e_1_2_8_24_1","article-title":"Pharmacogenetics of statin\u2010induced myopathy: a focused review of the clinical translation of pharmacokinetic genetic variants","volume":"5","author":"Talameh J.A.","year":"2014","journal-title":"J. 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