{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:57:24Z","timestamp":1791863844988,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u201089753"],"award-info":[{"award-number":["MOP\u201089753"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Rosuvastatin is commonly prescribed for the treatment of hypercholesterolemia and hepatic transporter\u2010mediated accumulation in the liver enhances its efficacy. Current guidelines indicate no preference for fed or fasted rosuvastatin administration. We investigated the association between food intake and rosuvastatin disposition in healthy subjects and low\u2010density lipoprotein cholesterol (LDL\u2010C)\u2010lowering effects among patients taking rosuvastatin. We demonstrate that administration with food resulted in a near 40% reduction of rosuvastatin exposure in healthy Asian (<jats:italic>n<\/jats:italic>\u2009=\u200912) and Caucasian (<jats:italic>n<\/jats:italic>\u2009=\u200911) subjects. Higher rosuvastatin concentrations in Asian subjects also correlated with higher allele frequency of <jats:italic>ABCG2<\/jats:italic> c.421C&gt;A. In mice, a greater rosuvastatin liver:plasma ratio was noted when administered with food. Among rosuvastatin patients (<jats:italic>n<\/jats:italic>\u2009=\u2009156), there was no difference in dose needed to reach target LDL\u2010C, measured LDL\u2010C, or lathosterol concentrations, when administered in a fed or fasting state. Therefore, taking rosuvastatin with food could reduce systemic concentrations, and subsequent myopathy risk, without compromising LDL\u2010C\u2010lowering benefit.<\/jats:p>","DOI":"10.1002\/cpt.973","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T08:06:46Z","timestamp":1512720406000},"page":"525-533","source":"Crossref","is-referenced-by-count":13,"title":["Food Effect on Rosuvastatin Disposition and Low\u2010Density Lipoprotein Cholesterol"],"prefix":"10.1111","volume":"104","author":[{"given":"Cheynne C.","family":"McLean","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology Western University London ON Canada"},{"name":"Department of Physiology &amp; Pharmacology Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Teft","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget L.","family":"Morse","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Gryn","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hegele","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Medicine Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology Western University London ON Canada"},{"name":"Department of Physiology &amp; Pharmacology Western University London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs313"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315665"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-12-200906160-00009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70601-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.12.009"},{"key":"e_1_2_9_8_1","first-page":"000099","article-title":"Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentration in routine clinical care","volume":"112","author":"DeGorter M.K.","year":"2013","journal-title":"Circ. 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