{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T20:26:38Z","timestamp":1750796798786},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":19726,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1962,1]]},"abstract":"<jats:p>This study establishes a method for differentiating between drug effects on the work performance of fatigued subjects. Sleep\u2010deprived subjects were assigned a boring and repetitious task of 5\u00bd hours' duration. The work output of subjects on D\u2010amphetamine (10 mg.), W1206 (10 mg.), or W1206 (20 mg.) was Significantly enhanced beyond that of subjects on meprobamate (800 mg.), amitriptyline (25 mg.), or a placebo. The group on amitriptyline showed a Significant retardation of performance compared to that of all other groups. D\u2010Amphetamine and W1206 appear to be effective antifatigue agents whereas placebo, meprobamate, and amitriptyline do not.<\/jats:p>","DOI":"10.1002\/cpt1962315","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:36:41Z","timestamp":1451954201000},"page":"5-15","source":"Crossref","is-referenced-by-count":17,"title":["Effects of drugs on the performance of a task by fatigued subjects"],"prefix":"10.1111","volume":"3","author":[{"given":"Audrey R.","family":"Holliday","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Devery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1962315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1962315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1962315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:29:27Z","timestamp":1699363767000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1962315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1962,1]]}},"alternative-id":["10.1002\/cpt1962315"],"URL":"https:\/\/doi.org\/10.1002\/cpt1962315","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1962,1]]}}}