{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T13:08:26Z","timestamp":1723986506373},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":18936,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1964,3]]},"abstract":"<jats:p>Tris is an effective, safe, rapidly acting amine buffer for the treatment of metabolic and mixed acidosis. It is useful in diminishing cardiac irritability associated with acidosis and in treating acidosis of cardiopulmonary bypass. This study reports the quantitative effects of Tris in 14 normal patients and 13 others with varying degrees of acidosis and alkalosis, primarily metabolic. In patients with a normal resting pH and in those with acidosis, the expected changes of hypoxia, hypoventilation, and hypocapnia appeared. In patients with initial alkalosis, hyperventilation and a tendency to increased pO<jats:sub>2<\/jats:sub> were comman. In the maiority of patients, particularly those with stable initial ventilation, controlled, mild alkalosis could be produced and maintained within narrow limits. Control of shifts in pH may be of value in the therapy of cardiac irritability associated with acidosis.<\/jats:p>","DOI":"10.1002\/cpt196452185","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:37:22Z","timestamp":1451954242000},"page":"185-192","source":"Crossref","is-referenced-by-count":7,"title":["Respiratory effects of Tris (THAM) in acidosis and alkalosis"],"prefix":"10.1111","volume":"5","author":[{"given":"Richard S.","family":"Cosby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Swan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196452185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196452185","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196452185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:50Z","timestamp":1699364030000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196452185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1964,3]]}},"alternative-id":["10.1002\/cpt196452185"],"URL":"https:\/\/doi.org\/10.1002\/cpt196452185","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,3]]}}}