{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T21:29:42Z","timestamp":1699651782280},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":18936,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1964,3]]},"abstract":"<jats:p>It is generally agreed that the precise quantitative assessment of drug\u2010induced respiratory depression presents many difficulties whether the measurements are attempted in animals or man. There has been considerable divergence between the claims made by manufacturers of narcotic analgesics and clinicians' experience with these drugs in practice. An attempt has been made to devise a simple and reliable technique which can be used in man to compare the respiratory depression produced by novel narcotic drugs and the standard drugs such as morphine and pethidine. To this end a modification of the carbon dioxide \u201cchallenge\u201d test was used in this investigation, and four possible measures were considered. The best indices of respiratory depression were shown to be (a) the absolute value of the alveolar ventilation while a 95 per cent O<jats:sub>2<\/jats:sub>\/5 per cent CO<jats:sub>2<\/jats:sub> mixture is breathed and (b) the change in the arterial carbon dioxide tension from the control level during carbon dioxide stimulation to respiration. Both measurements were made 10 to 20 minutes following intravenous injection of the test drug.<\/jats:p>","DOI":"10.1002\/cpt196452193","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:37:22Z","timestamp":1451954242000},"page":"193-200","source":"Crossref","is-referenced-by-count":11,"title":["Drug\u2010induced respiratory depression in man: A method of assessment"],"prefix":"10.1111","volume":"5","author":[{"given":"D.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Lister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. W.","family":"McNicol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196452193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196452193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196452193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:05Z","timestamp":1699363985000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196452193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1964,3]]}},"alternative-id":["10.1002\/cpt196452193"],"URL":"https:\/\/doi.org\/10.1002\/cpt196452193","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,3]]}}}