{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:04:17Z","timestamp":1758474257718},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":18326,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1965,11]]},"abstract":"<jats:p>Chlorpromazine and promazine were found to potentiate certain effects of JB\u2010329 and atropine in a group of psychiatric patients. These effects were measured by a JB\u2010<jats:sup>329<\/jats:sup> rating scale, 80 items grouped to yield nine cluster scores. This scale allowed a differenrtiation of the particular aspects potentiated by chlorpromazine and promazine. This potentiation was observed on three scores: neurological impairment, loss of consciousness, and impaired performance on the Bender\u2010Gestalt test. Imipramine did not show any such potentiation on this scale and was similar in effect to a saline control. THA and yohimbine were found to antagonize the effects produced by the combination of an anticholinergic and a phenothiazine compound. The effects of these drug combinations were similar to those observed in dogs, but not to the findings in smaller animals (mice and rats).<\/jats:p>","DOI":"10.1002\/cpt196566749","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:37:52Z","timestamp":1451954272000},"page":"749-756","source":"Crossref","is-referenced-by-count":15,"title":["Interaction between some anticholinergic agents and phenothiazines: Potentiation of phenothiazine sedation and its antagonism"],"prefix":"10.1111","volume":"6","author":[{"given":"Samuel","family":"Gershon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Sundland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196566749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196566749","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196566749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:30:36Z","timestamp":1699363836000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196566749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1965,11]]}},"alternative-id":["10.1002\/cpt196566749"],"URL":"https:\/\/doi.org\/10.1002\/cpt196566749","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,11]]}}}