{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:47:53Z","timestamp":1771645673356,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":17353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:p>In a review of the pharmacology of amino acids twenty years ago,<jats:sup>16<\/jats:sup> it was stated that \u201csimple amino\u2010acids do not show startling drug reactions.\u201d This statement is basically true today, but in the intervening years amino acids which are not constituents of protein have been discovered at an average rate of about ten per year.<jats:sup>157<\/jats:sup> In addition, there has been an awakening of interest in the effects of general and specific amino acid excess and deficiency, and a realization that chronic amino acid imbalance, found in one of the most common of human diseases, malnutrition, and in the rare but instructive inborn errors of amino acid metabolism, gives important information of the pharmacology of amino acids in man. In a discussion of the pharmacology of important natural products the boundaries between physiology and pharmacology become blurred, but in this review the latter aspect will naturally be emphasized.<\/jats:p>","DOI":"10.1002\/cpt196894484","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:47:55Z","timestamp":1451954875000},"page":"484-516","source":"Crossref","is-referenced-by-count":17,"title":["Pharmacology of amino acids"],"prefix":"10.1111","volume":"9","author":[{"given":"M. D.","family":"Milne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196894484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196894484","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196894484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:35:10Z","timestamp":1699364110000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196894484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1968,7]]}},"alternative-id":["10.1002\/cpt196894484"],"URL":"https:\/\/doi.org\/10.1002\/cpt196894484","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,7]]}}}