{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:19:28Z","timestamp":1792192768112,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":17291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1968,9]]},"abstract":"<jats:p>Previously published plasma concentrations of LSD\u201025, observed following intravenous iniection of 2 mcg. per kilogram of LSD\u201025, have been found to be explained by the two\u2010compartment open model. Performance scores on arithmetic tests were shown to be highly linearly correlated with the concentration in the \u201ctissue\u201d (outer) compartment. The estimated volume of the plasma (inner) compartment was 16.3 per cent of body weight, which is approximately the value reported for extracellular water; the estimated volume of the tissue compartment was 11.5 per cent of body weight. The estimated half\u2010life for loss of LSD\u201025 from the plasma compartment, based on the model, was 103 minutes compared with a half\u2010life of 180 minutes calculated directly from plasma concentrations.<\/jats:p>","DOI":"10.1002\/cpt196895635","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:52:20Z","timestamp":1451955140000},"page":"635-638","source":"Crossref","is-referenced-by-count":55,"title":["Correlation of performance test scores with \u201ctissue concentration\u201d of lysergic acid diethylamide in human subiects"],"prefix":"10.1111","volume":"9","author":[{"given":"John G.","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Aghajanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar H. L.","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196895635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196895635","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196895635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:28:59Z","timestamp":1699363739000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196895635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1968,9]]}},"alternative-id":["10.1002\/cpt196895635"],"URL":"https:\/\/doi.org\/10.1002\/cpt196895635","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,9]]}}}