{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:45:49Z","timestamp":1792100749534,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":17291,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1968,9]]},"abstract":"<jats:p>Analgesic potency of graded doses of a combination of orphenadrine with the common APe tablet was tested and compared with each of its ingredients and a placebo in a double blind study. The subiects were 325 patients whose pain was largely associated with muscle spasm. Pain responses were scored at 6 hourly intervals after a single administration of medication. The data were analyzed by 3 statistical methods. Results show the combination to have a sustained pain\u2010relieving action and a statistically significant faster onset of analgesia than either of its components or placebo. Unexpected drug reactions were minimal.<\/jats:p>","DOI":"10.1002\/cpt196895639","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T00:52:20Z","timestamp":1451955140000},"page":"639-646","source":"Crossref","is-referenced-by-count":18,"title":["Drug combinations with orphenadrine for pain relief associated with muscle spasm"],"prefix":"10.1111","volume":"9","author":[{"suffix":"Jr.","given":"J. W.","family":"Birkeland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. K.","family":"Clawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196895639","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt196895639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt196895639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:33Z","timestamp":1699364013000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt196895639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1968,9]]}},"alternative-id":["10.1002\/cpt196895639"],"URL":"https:\/\/doi.org\/10.1002\/cpt196895639","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,9]]}}}