{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:21:35Z","timestamp":1771644095100,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":17169,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1969,1]]},"abstract":"<jats:p>Cigarette smoking markedly increases the activity of enzymes in human placenta which hydroxylate 3,4\u2010benzpyrene and N\u2010demethylate 3\u2010methyl\u20104\u2010monomethylaminoazobenzene. No detectable benzpyrene hydroxylase or aminoazo dye N\u2010demethylase activity was observed in 17 human placentas obtained after childbirth from nonsmokers, but these enzymes were found in the placentas obtained from 17 smokers. Considerable variability in benzpyrene hydroxylase activity was observed in placentas that were obtained from women who smoke the same number of cigarettes. Several polycyclic aromatic hydrocarbons which are present in cigarette smoke were tested for ability to induce benzpyrene hydroxylase in rat placenta. Treatment of pregnant rats with 3,4\u2010benzpyrene, 1,2\u2010benzanthracene, 1,2,5,6\u2010dibenzanthracene, chrysene, 3,4\u2010benzofluorene, anthracene, pyrene, fluoranthene, perylene, or phenanthrene increased benzpyrene hydroxylase activity in the placenta.<\/jats:p>","DOI":"10.1002\/cpt1969101100","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:01:30Z","timestamp":1451955690000},"page":"100-109","source":"Crossref","is-referenced-by-count":147,"title":["Stimulatory effect of cigarette smoking on the hydroxylation of 3,4\u2010benzpyrene and the N\u2010demethylation of 3\u2010methyl\u20104\u2010monomethylaminoazobenzene by enzymes in human placenta"],"prefix":"10.1111","volume":"10","author":[{"given":"R. M.","family":"Welch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. E.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. W.","family":"Gommi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Poppers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Finster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Conney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1969101100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1969101100","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1969101100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:34:42Z","timestamp":1699364082000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1969101100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1969,1]]}},"alternative-id":["10.1002\/cpt1969101100"],"URL":"https:\/\/doi.org\/10.1002\/cpt1969101100","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,1]]}}}