{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:04Z","timestamp":1786977484710,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":16623,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1970,7]]},"abstract":"<jats:p>The specific aims of the double\u2010blind study were to compare the analgesic effectiveness of morphine (10 mg. per milliliter), meperidine (75 mg. per milliliter), fentanyl (0.1 mg. per milliliter), and fentanyl\u2010droperidol (0.1 to 2.5 mg. per milliliter) in patients subjected to routine medical and dental procedures at a metropolitan general hospital. The (4 x 3) analysis of variance design included the 4 drugs with observations on analgesia, vital signs, and blood chemistry 15, 30, or 45 minutes after drug infection. No significant differences in degree of relief from pain were observed among the 4 drugs or the 3 postinjection intervals. There was a significant interaction in the degree of relief by the 4 drugs with the 3 postinjection time intervals. The fentanyl\u2010droperidol combination provided a greater and more prompt degree of relief at 15 than at 30 or 45 minutes. Significant differences were not observed in manifest anxiety or frequency of nausea among the patients. No Significant differences were observed in vital signs, blood protein, glucose, cholesterol, or corticosterone levels among the 4 drug groups. Significant differences in blood glucose, cholesterol, and corticosterone were noted among the 3 postinjection time intervals.<\/jats:p>","DOI":"10.1002\/cpt1970114488","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T20:10:00Z","timestamp":1451938200000},"page":"488-495","source":"Crossref","is-referenced-by-count":3,"title":["Comparisons of effects of morphine, meperidine, fentanyl, and fentanyl\u2010droperidol"],"prefix":"10.1111","volume":"11","author":[{"given":"J. M.","family":"Ordy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. E.","family":"Kretchmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Gorry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Hershberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1970114488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1970114488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1970114488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:33:59Z","timestamp":1699346039000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1970114488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1970,7]]}},"alternative-id":["10.1002\/cpt1970114488"],"URL":"https:\/\/doi.org\/10.1002\/cpt1970114488","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,7]]}}}