{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:58:04Z","timestamp":1756994284336},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15953,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:p>A double\u2010blind trial was carried out on 22 volunteer patients to observe the influence of nitrazepam on the course of long\u2010term anticoagulant therapy with phenprocoumon. Dosage of phenprocoumon remained unchanged for all patients during the 8 week trial. Nitrazepam or placebo, assigned at random, was taken every night for a 2 week period; a subsequent 2 week period without test drugs was followed by a second series with the other tablet. The last 2 weeks of the trial were without test drugs. There was no difference between the effects of the placebo and the nitrazepam on the hypocoagulability due to the oral anticoagulant therapy. It is concluded that nitrazepam can safely be prescribed as a hypnotic for patients on long\u2010term anticoagulant therapy.<\/jats:p>","DOI":"10.1002\/cpt1972133361","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:17:23Z","timestamp":1451956643000},"page":"361-365","source":"Crossref","is-referenced-by-count":9,"title":["Influence of nitrazepam on oral anticoagulation with phenprocoumon"],"prefix":"10.1111","volume":"13","author":[{"given":"Robert","family":"Bieger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil A.","family":"Loeliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1972133361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1972133361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1972133361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:45Z","timestamp":1699364025000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1972133361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,5]]}},"alternative-id":["10.1002\/cpt1972133361"],"URL":"https:\/\/doi.org\/10.1002\/cpt1972133361","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,5]]}}}