{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:37:17Z","timestamp":1764085037116},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15343,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>The effects of chronic steroid contraceptive use on drug\u2010metabolizing activity were studied by using plasma antipyrine (ap) and phenylbutazone (pbz) half\u2010lives in women and in vitro N\u2010demethylation of O\u2010ethylmorphine by female rat liver preparations. After 3 months of oral steroid therapy (norethynodrel plus mestranol), the antipyrine half\u2010life was increased in 5 of 8 sub;ects (as compared to their previous half\u2010lives), whereas the pbz half\u2010life was not COnsistently altered. After chronic injections of norethynodrel\u2010mestranol (200 p.g per rat per day plus 4 p.g per rat per day, respectively) for 10 days or 6 weeks, ethylmorphine demethylation by rat livers was significantly increased. A higher dose of norethynodrel\u2010mestranol but not a lower dose also stimulated ethylmorphine demethylation activity. The acute addition of norethynodrel or mestranol in vitro competitively inhibited ethylmorphine demethylation. Under the conditions of the observations, therefore, the rat cannot be used as a model for the effects of the chronic use of oral steroid contraceptives in women.<\/jats:p>","DOI":"10.1002\/cpt197415122","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:24:04Z","timestamp":1451957044000},"page":"22-31","source":"Crossref","is-referenced-by-count":39,"title":["Effect of oral contraceptives on drug metabolism"],"prefix":"10.1111","volume":"15","author":[{"given":"Dean E.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubin","family":"Bressler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan J.","family":"Huxtable","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Donald","family":"Christian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Wayne","family":"Heine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197415122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197415122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt197415122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:32:01Z","timestamp":1699363921000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt197415122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1002\/cpt197415122"],"URL":"https:\/\/doi.org\/10.1002\/cpt197415122","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}