{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:06:42Z","timestamp":1776186402153,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15343,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1974,1]]},"abstract":"<jats:p>The levels of fluorocarbon\u201011 and fluorocarbon\u201012 (F\u201011, CCl<jats:sub>3<\/jats:sub>F; F\u201012, CCl<jats:sub>2<\/jats:sub>F<jats:sub>2<\/jats:sub>) have been measured in arterial blood of 8 asthmatics after using an aerosol inhaler. Following two puffs with a 30 second interval, peak arterial plasma levels ranged from 0.53 to 3.1 \u00b5g per milliliter (F\u201011) and 0.2 to 3.13 \u00b5g per milliliter (F\u201012); folloWing a single puff peak levels were 0.26 to 2.0 J.lg per milliliter (F\u201011) and 0 to 2.3 J.lg per milliliter (F\u201012). The peak level was achieved 10 to 20 seconds after the inhalation, followed by a rapid fall in arterial level. The measured levels have been compared with predicted values using a computer model. This model has been used to predict the myocardial concentration in man from the measured arterial levels. Except with grossly excessive use of an aerosol inhaler in a short period of time, the predicted myocardial concentrations of fluorocarbon in man are much less than the levels shown to sensitize the heart of conscious normal dogs to epinephrine.<\/jats:p>","DOI":"10.1002\/cpt197415159","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:24:04Z","timestamp":1451957044000},"page":"59-66","source":"Crossref","is-referenced-by-count":45,"title":["Arterial blood levels of fluorocarbons in asthmatic patients following use of pressurized aerosols"],"prefix":"10.1111","volume":"15","author":[{"given":"C. T.","family":"Dollery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith M.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Draffan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sahyoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197415159","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197415159","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt197415159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:34:08Z","timestamp":1699364048000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt197415159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["10.1002\/cpt197415159"],"URL":"https:\/\/doi.org\/10.1002\/cpt197415159","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}