{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:31:36Z","timestamp":1759541496854},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1974,4]]},"abstract":"<jats:p>The narcotic antagonists oXilorphan and d,l\u2010cyclazocine increased urinary output without affecting fluid intake in 10 subjects on ad libitum fluids. 1n 8 water\u2010deprived subjects oXilorphan increased urinary output and decreased urine osmolality without significantly altering blood pressure, creatinine clearance, electrolyte excretion, or solute excretion. Three of 4 water\u2010loaded subjects excreted a water load slightly more efficiently after the drug. Ten milligrams of naloxone had no diuretic effect itself and did not antagonize the diuretic effect of oxilorphan. Five units of vasopressin prevented the drug\u2010induced diuresis. These results suggest that the diuretic effect is an agonistic action of oXilorphan produced by inhibition of antidiuretic hormone (ADH) release.<\/jats:p>","DOI":"10.1002\/cpt1974154361","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:28:07Z","timestamp":1451957287000},"page":"361-367","source":"Crossref","is-referenced-by-count":19,"title":["Diuretic action of the narcotic antagonist oxilorphan"],"prefix":"10.1111","volume":"15","author":[{"given":"John G.","family":"Nutt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Jasinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974154361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974154361","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1974154361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:35:16Z","timestamp":1699364116000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1974154361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1974,4]]}},"alternative-id":["10.1002\/cpt1974154361"],"URL":"https:\/\/doi.org\/10.1002\/cpt1974154361","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,4]]}}}