{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T12:45:15Z","timestamp":1749127515167},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15253,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1974,4]]},"abstract":"<jats:p><jats:sup>14<\/jats:sup>C\u2010DMHP (200 \u00b5g\/70 kg man) was administered by the intravenous route to 3 healthy male casual marihuana smokers. Tachycardia occurred within 10 minutes and persisted for from 11 1\/2 to 6 hours. Blood pressure fell slightly with time when subiects were supine, while standing for less than 1 minute resulted in marked hypotension. In these 3 subjects, except for dizziness on standing there were essentially no demonstrable psychologic effects, neither euphoria nor dysphoria. Subiects did, however, report symptoms similar to those after marihuana or \u0394<jats:sup>9<\/jats:sup>\u2010THC, including dry mouth, decreased salivation, and drowsiness. After intravenous dimethyl heptyl tetrahydrocannabinol (DMHP), plasma levels of total radioactivity and <jats:sup>14<\/jats:sup>C\u2010DMHP declined in a multiphasic fashion; the half\u2010life of the terminal phase for DMHP was 39 hours. Approximately 69% of the administered radioactive dose was recovered in 7 days. Radioactivity was excreted predominantly in the feces (58%) and to a lesser extent in urine (11%) during the 7 day collection period.<\/jats:p>","DOI":"10.1002\/cpt1974154380","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:28:07Z","timestamp":1451957287000},"page":"380-386","source":"Crossref","is-referenced-by-count":18,"title":["Pharmacologic effects and physiologic disposition of delta<sup>6a,10a<\/sup> dimethyl heptyl tetrahydrocannabinol (DMHP) in man"],"prefix":"10.1111","volume":"15","author":[{"given":"Louis","family":"Lemberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"McMahon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Archer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974154380","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974154380","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1974154380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:32:35Z","timestamp":1699363955000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1974154380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1974,4]]}},"alternative-id":["10.1002\/cpt1974154380"],"URL":"https:\/\/doi.org\/10.1002\/cpt1974154380","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,4]]}}}