{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:07:09Z","timestamp":1762067229664},"reference-count":0,"publisher":"Wiley","issue":"5part1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":15039,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>Problems associated with the excessive consumption of alcohol are recorded as early as in the Book of Genesis, whereas the abuse of the synthetic sedatives is obviously of much more recent origin. Although a wide range of sedatives are misused,<jats:sup>19<\/jats:sup> the problem is seen principally with the barbiturates. While many aspects of the biochemical pharmacology of alcohol and of the barbiturates are widely dissimilar, there is a considerable cross\u2010tolerance between them and they are alike in that rapid development of tolerance can occur as the result of a single exposure to either of them, a point which is reviewed for both groups together at the end of this article.<\/jats:p>","DOI":"10.1002\/cpt1974165part1737","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:36:53Z","timestamp":1451957813000},"page":"737-749","source":"Crossref","is-referenced-by-count":17,"title":["The biochemical pharmacology of abused drugs; II. Alcohol and barbiturates"],"prefix":"10.1111","volume":"16","author":[{"given":"John","family":"Caldwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Sever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974165part1737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1974165part1737","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1974165part1737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:34:18Z","timestamp":1699364058000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1974165part1737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,11]]},"references-count":0,"journal-issue":{"issue":"5part1","published-print":{"date-parts":[[1974,11]]}},"alternative-id":["10.1002\/cpt1974165part1737"],"URL":"https:\/\/doi.org\/10.1002\/cpt1974165part1737","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1974,11]]}}}