{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:17:32Z","timestamp":1757542652558},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":14919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1975,3]]},"abstract":"<jats:p>Simultaneous serum, urine, and bile measurements of digitoxin and its cardioactive metabolites were performed in 5 cholecystectomized patients with T tube drainage. A <jats:sup>86<\/jats:sup>Rb method was used for serum and urine analysis. The recovery of digitoxin and cardioactive metabolites in two extractions with dichloromethane was 93%; 7% was left in bile. Peak bile concentrations had a mean value of 41.6 ng\/ml and were seen after 15 to 60 min. Bile concentration was higher than serum and urine concentration after 24 hr. Mean T\/2 of serum elimination was 4.3 days and 8.1 days in 5 control subjects (p &lt; 0.01). Mean urine concentration T\/2 was 10.4 days and 7.2 days in the control subjects (not significant). Mean bile concentration T\/2 was 3.5 days. Urinary excretion of digitoxin and cardioactive metabolites was the same in the two groups. The biliary fistula group excreted 22.5% in urine and bile of a dose after 8 days, whereas it was 15.8% in the control subjects. The ratio between the cumulative excretion in urine and bile varied between 1.6 and 2.2. These findings demonstrate that direct interruption of the enterohepatic circulation leads to a marked reduction in serum half\u2010time of digitoxin and cardioactive metabolites, but T\/2 is still longer than for other glycosides, indicating that factors other than the enterohepatic circulation are of importance in the slow elimination of digitoxin.<\/jats:p>","DOI":"10.1002\/cpt1975173313","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:36:59Z","timestamp":1451957819000},"page":"313-320","source":"Crossref","is-referenced-by-count":24,"title":["Studies on digitalis. III. Biliary excretion and enterohepatic circulation of digitoxin and its cardioactive metabolites"],"prefix":"10.1111","volume":"17","author":[{"given":"Liv","family":"Storstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1975173313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1975173313","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1975173313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:35:18Z","timestamp":1699364118000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1975173313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1975,3]]}},"alternative-id":["10.1002\/cpt1975173313"],"URL":"https:\/\/doi.org\/10.1002\/cpt1975173313","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,3]]}}}