{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:58:20Z","timestamp":1770220700894,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":14461,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1976,6]]},"abstract":"<jats:p>Tocainide, a primary amine analogue of lidocaine, is effective against some experimental and clinical arrhythmias. Its pharmacokinetic behavior was studied in 6 healthy male subjects. Peak blood levels (C<jats:sub>B<\/jats:sub> max) and area under the blood concentration\u2010time curve (AUC) were linearly related to dose with slopes of 0.0067 mcg\/ml and 6 min mcg\/ml per milligram of dose, respectively. Renal clearance of tocainide averaged 59 ml\/min when urinary pH was uncontrolled or acidified, while it was reduced to 13 ml\/min during intense sodium bicarbonate loading. Blood levels following intravenous infusion were well described by a 2\u2010compartment open model with a volume of the central compartment of 0.92 L\/kg. The t<jats:sub>1\/2\u03b2<\/jats:sub> was 11 hr and total body clearance was 166 ml\/min. Loo\u2010Riegelman analysis of the absorption rate did not allow unequivocal assignment of an \u201corder\u201d to the absorption process. Bioavailability approached 100%. Administration of drug 5 min after a test meal suppressed C<jats:sub>B<\/jats:sub> max 40% but minimally affected AUC. Approximately 50% of the drug was found to be plasma protein bound at clinically effective concentrations.<\/jats:p>","DOI":"10.1002\/cpt1976196757","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:45:01Z","timestamp":1451958301000},"page":"757-766","source":"Crossref","is-referenced-by-count":89,"title":["Kinetics of the oral antiarrhythmie lidocaine congener, tocainide"],"prefix":"10.1111","volume":"19","author":[{"given":"David","family":"Lalka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin B.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin R.","family":"Duce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred T.","family":"Elvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1976196757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1976196757","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1976196757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:29:57Z","timestamp":1699363797000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1976196757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1976,6]]}},"alternative-id":["10.1002\/cpt1976196757"],"URL":"https:\/\/doi.org\/10.1002\/cpt1976196757","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,6]]}}}