{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:19:27Z","timestamp":1699402767607},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":14066,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1977,7]]},"abstract":"<jats:p>Reviews of large series of patients with digitalis\u2010induced arrhythmias create a seeming paradox: Hypokalemia is infrequently associated with digitalis\u2010induced arrhythmias but the clinical benefit of supplementation of potassium for most digitalis\u2010induced arrhythmias is obvious. Examination of the electrophysiologic abnormalities induced by digitalis coupled with the electrophysiologic effects dependent on the ratio of intracellular to extracellular concentrations of potassium clarifies the issue. We present evidence that supports additive effects ol the toxicity of digitalis and abnormal ratios of concentrations of potassium inside and outside the cardiac cell. We provide guidelines for assessing this aucial ratio of intracellular to extracellular concentrations of potassium to aid the clinician in the diagnosis and effective treatment of digitalis\u2010induced arrhythmias.<\/jats:p>","DOI":"10.1002\/cpt197722121","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:48:26Z","timestamp":1451958506000},"page":"21-33","source":"Crossref","is-referenced-by-count":16,"title":["Digoxin toxicity in patients with normokalemic potassium depletion"],"prefix":"10.1111","volume":"22","author":[{"given":"D. Craig","family":"Brater","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard F.","family":"Morrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197722121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt197722121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt197722121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:03Z","timestamp":1699363983000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt197722121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,7]]}},"alternative-id":["10.1002\/cpt197722121"],"URL":"https:\/\/doi.org\/10.1002\/cpt197722121","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,7]]}}}