{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T07:30:55Z","timestamp":1757575855059},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":14035,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1977,8]]},"abstract":"<jats:p>Since morphine alters ventilatory drive during chemoreceptor stimulation, we have examined whether it produces a similar resetting of the hypercapnia\u2010induced arteriolar constrictor rejiex. In 11 normal subjects, forearm blood jiow (FBF) was measured plethysmographically and forearm vascular resistance (FVR) was calculated before and during hypercapnia induced by a rebreathing technique. An increase in arterial carbon dioxide tension (P <jats:sup>a<\/jats:sup>C0<jats:sup>2<\/jats:sup>) (16.8 \u00b1 1.1 mm Hg) increased FVR by 30.5 \u00b1 4.8 mm Hg\/ml\/min . 100 ml (55.1 \u00b1 5.1 to 85.6 \u00b1 9.0). Fifteen minutes after intravenous administration of 15 mg ofmorphine sulfate (MS), a similar increase in P aC02 (\/6.6 \u00b1 1.2 mm Hg) caused an increase in FVR of 16.7 \u00b1 3.9 mm Hg\/ml\/min . 100 ml (34.1 \u00b1 4.1 to 50.8 \u00b1 6.7). The change in FVR with CO<jats:sup>2<\/jats:sup>during MS was less than that before MS (p &lt; 0.02). When the sequential response patterns to CO<jats:sup>2<\/jats:sup> challenge were determined, it was found that, prior to MS, the FVR increase occurred as a late response to hypercapnia, but after MS the late increase in FVR did not occur and in several subjects there was a general tendency toward net vasodilation. An MS\u2010induced resetting of the constrictor rejiex mechansim to CO<jats:sup>2<\/jats:sup> must therefore have tended to unmask the direct dilator properties of the CO<jats:sup>2<\/jats:sup>. Such a dilation caused by hypercapnia and unopposed by the normal rejiex mechanism may partially explain the hypotensive effect of MS when administered to susceptible patients with CO<jats:sup>2<\/jats:sup> retention . The attenuated chemoreceptor rejiex\u2010induced arteriolar constriction due to CO<jats:sup>2<\/jats:sup> stimulation may also explain the withdrawal of alpha adrenergic tone which occurs when MS is given to normal subjects. This alteration in the chemoreceptor rejiex mechanism may occur at the level of the central nervous system since naloxone effectively restored the rejiex response to normal.<\/jats:p>","DOI":"10.1002\/cpt1977222172","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:48:59Z","timestamp":1451958539000},"page":"172-178","source":"Crossref","is-referenced-by-count":13,"title":["Effects of morphine on reflex arteriolar constriction induced in man by hypercapnia"],"prefix":"10.1111","volume":"22","author":[{"given":"Robert","family":"Zelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen F.","family":"Flaim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Eiseie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1977222172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1977222172","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1977222172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:28:49Z","timestamp":1699363729000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1977222172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,8]]}},"alternative-id":["10.1002\/cpt1977222172"],"URL":"https:\/\/doi.org\/10.1002\/cpt1977222172","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,8]]}}}