{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:35:40Z","timestamp":1790145340119,"version":"4.0.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13974,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1977,10]]},"abstract":"<jats:p>lntersubject differences in the volume of distribution, whole body clearance, and steady\u2010state plasma concentrations of salicylic acid (SA) were studied in a series of patients with rheumatoid arthritis and healthy control subjects. The measurement of the plasma concentration of SA 12 hr after an oral dose of 1.2 gm aspirin appears predictive of the success of long\u2010term dosage of aspirin. Concentrations below 5 u\u2010g\/ml in this single\u2010dose test were associated with failure to achieve therapeutic plasma concentrations of SA (above 150 u\u2010g\/ml) during long\u2010term therapy with approximately 4.8 gm aspirin per day. Conversely, plasma concentrations above 10 u\u2010g\/ml in the single\u2010dose test were associated with levels above 150 u\u2010g\/ml during long\u2010term therapy. The volume of distribution of SA correlated poorly with body weight (r = 0.51, P &lt; 0.01) and did not correlate significantly with plasma albumin levels. Corticosteroids appear to induce the metabolism of SA and most subjects dosed with oral corticosteroids and aspirin 4.8 gm\/day did not attain plasma levels of SA above 150 u\u2010g\/ml. The clearance of SA was greater in male than in female patients. The difference appears to be of clinical significance since fewer men than women achieved therapeutic plasma concentrations of SA.<\/jats:p>","DOI":"10.1002\/cpt1977224410","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:50:03Z","timestamp":1451958603000},"page":"410-420","source":"Crossref","is-referenced-by-count":86,"title":["Patterns of plasma concentrations and urinary excretion of salicylate in rheumatoid arthritis"],"prefix":"10.1111","volume":"22","author":[{"given":"G. G.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D.","family":"Champion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. O.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"Paull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1977224410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1977224410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1977224410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:31:55Z","timestamp":1699363915000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1977224410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,10]]}},"alternative-id":["10.1002\/cpt1977224410"],"URL":"https:\/\/doi.org\/10.1002\/cpt1977224410","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,10]]}}}