{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T05:43:53Z","timestamp":1757569433665},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13823,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:p>Normal male volunteers on xanthine\u2010restricted diets had a plasma theobromine (TB) half\u2010life (t<jats:sup>\u00bd<\/jats:sup>) of6.1 \u00b1 0.7 hr (mean \u00b1 SEM), a TB metabolic clearance rate (MCR) of 113.8 \u00b1 6.8 mllmin (mean \u00b1 SEM). and an apparent volume of distribution (aVd) of 59.9 \u00b1 7.8 L (mean \u00b1 SEM) after a single oral dose of6 mg\/kg of TB. A two\u2010week period of dietary abstention from methylxanthines shortened the mean plasma TB t<jats:sup>\u00bd<\/jats:sup> by 33% and increased the mean MCR ofTB by 59%; no change occurred in mean aVd of TB. In another experiment, normal male volunteers received the same oral dose of TB for each of five consecutive days. The mean plasma TB t<jats:sup>\u00bd<\/jats:sup> measured immediately after the last TB dose was prolonged by almost two\u2010thirds, while the mean aVd increased 23%. Although the mean plasma TB t<jats:sup>\u00bd<\/jats:sup> measured four days after this last TB dose was the same as that measured after a single oral dose, the mean MCR of TB increased by 34%, but this change was balanced by increased mean aVd of 35%. These results suggest that immediately after five daily doses ofTB, an impairment ofTB clearance occurs that is reversible by four days of dietary abstention from methylxanthines.<\/jats:p>","DOI":"10.1002\/cpt1978233296","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:53:31Z","timestamp":1451958811000},"page":"296-302","source":"Crossref","is-referenced-by-count":46,"title":["Studies on theobromine disposition in normal subjects; Alterations induced by dietary abstention from or exposure to methylxanthines"],"prefix":"10.1111","volume":"23","author":[{"given":"Dennis D.","family":"Drouillard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot S.","family":"Vesell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry H.","family":"Dvorchik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978233296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978233296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978233296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:28:41Z","timestamp":1699363721000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978233296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3]]}},"alternative-id":["10.1002\/cpt1978233296"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978233296","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3]]}}}