{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:07:41Z","timestamp":1776186461092,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13823,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:p>A radiotracer technique is described which enables direct measurement of the dose and distribution of inhaled aerosol bronchodilator in man. The mean (\u00b1SD) amounts of the B<jats:sub>2<\/jats:sub>\u2010adrenergic agonist, fenoterol, administered to a group of 12 asthmatic subjects in a double\u2010blind randomized fashion were: placebo, 0 \u00b5g; low dose, 5.6 (\u00b1 1.2) \u00b5g; medium dose, 32.7 (\u00b17.3) \u00b5g; and high dose, 127.5 (\u00b129.2) \u00b5g, with a mean of 86.3% of the total subject dose being deposited in the lungs. The medium and high doses of fenoterol produced similar increases above baseline in forced expired volume in 1 sec (FEV<jats:sub>1<\/jats:sub>), maximum flow at 50% of vital capacity (V<jats:sub>max 50<\/jats:sub>), and maximum flow at 25% of vital capacity (V<jats:sub>max 25<\/jats:sub>). These increases were greater than those with placebo for the entire 4\u2010hr study (p &lt; 0.01). The low dose of fenoterol was more effective than placebo in increasing FEV<jats:sub>1<\/jats:sub>, V<jats:sub>max 50<\/jats:sub>, and V<jats:sub>max 25<\/jats:sub> above baseline values (p &lt; 0.05), but not for the entire 4\u2010hr study. The high\u2010dose fenoterol caused palpitations and tremor in 3 of the 12 subjects, and the medium\u2010dose fenoterol caused palpitations in one of these subjects.<\/jats:p>","DOI":"10.1002\/cpt1978233338","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:53:31Z","timestamp":1451958811000},"page":"338-345","source":"Crossref","is-referenced-by-count":49,"title":["Response of asthmatic patients to fenoterol inhalation: A method of quantifying the airway bronchodilator dose"],"prefix":"10.1111","volume":"23","author":[{"given":"R. E.","family":"Ruffin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Kenworthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Newhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978233338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978233338","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978233338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:28:41Z","timestamp":1699363721000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978233338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,3]]}},"alternative-id":["10.1002\/cpt1978233338"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978233338","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3]]}}}