{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:20:48Z","timestamp":1699402848181},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13792,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:p>The analgesic efficacy of fendosal, a new nonsteroidal anti\u2010inflammatory agent structurally related to salicylic acid, was compared with that of aspirin and placebo in 100 patients with postpartum uterine pain in a single oral dose, parallel, stratified, randomized, double\u2010blind design. With 650 mg aspirin and with 200 or 400 mg fendosal, but not with 100 mg, analgesic effects, as measured subjectively by mean pain intensity scores, began within 1 hr and had similar time\u2010effect patterns for the first 4 or 5 hr. Thereafter with the 2 higher doses of fendosal analgesia continued to increase, reaching a peak at 6 hr (p &lt; 0.05) and persisting beyond 7 hr (p &lt; 0.01), whereas there was no aspirin analgesia after the fifth hour. With 100 mg fendosal time of onset tended to be delayed 2 hr or more, and duration was short. The most effective treatment (largest mean 7\u2010hr sum of pain intensity difference [SPID] score) was 400 mg fendosal (p &lt; 0.01); 200 mg fendosal was rated second (p &lt; 0.01), 650 mg aspirin, third (p &lt; 0.05), 100 mg fendosal, fourth, and placebo, fifth. There were no significant side effects. These results demonstrate the efficacy of single doses of fendosal as well as the dose\u2010dependent magnitude and time course of effect on postpartum uterine pain.<\/jats:p>","DOI":"10.1002\/cpt1978234390","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:54:59Z","timestamp":1451958899000},"page":"390-396","source":"Crossref","is-referenced-by-count":8,"title":["Fendosal and aspirin in postpartum uterine pain"],"prefix":"10.1111","volume":"23","author":[{"given":"Saul S.","family":"Bloomfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom P.","family":"Barden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978234390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978234390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978234390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:30:40Z","timestamp":1699363840000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978234390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1002\/cpt1978234390"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978234390","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,4]]}}}