{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T16:32:16Z","timestamp":1722616336210},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13762,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>We conducted a 7\u2010month randomized, single, double, single\u2010blind comparison of calcitriol (1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) with vitamin D<jats:sub>3<\/jats:sub> in 22 hemodialysis patients to study the effects on the biochemical abnormalities associated with osteodystrophy. Calcitriol was given for 3 mo. All patients had initial pre study calcium values \u22649.5 mg\/100 ml, and phosphate values \u22644.5 mg\/100 ml. Data were analyzed using the Normalized Trend Index (NTI). Calcitriol induced a rise in calcium (8.7 to 10.25 mg\/100 ml) (p &lt; 0.001) and a fall in alkaline phosphatase (p &lt; 0.005), while D<jats:sub>3<\/jats:sub> had no appreciable effect. The mean dose of calcitriol during treatment was 0.579 \u00b5g\/day while that for D<jats:sub>3<\/jats:sub> was 706 IU\/day. The effect on serum phosphate concentration was variable. Hypercalcemia as high as 13.2 mg\/100 ml occurred in 2 of 13 patients on 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, but in every instance promptly returned to normal with dose reduction. No other adverse effects were noted with therapy. We conclude that calcitriol reverses the biochemical abnormalities of osteodystrophy. Since its effects are rapidly reversed with discontinuation, the drug is probably safe as well as effective.<\/jats:p>","DOI":"10.1002\/cpt1978235515","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:56:55Z","timestamp":1451959015000},"page":"515-519","source":"Crossref","is-referenced-by-count":9,"title":["Calcitriol in dialysis patients"],"prefix":"10.1111","volume":"23","author":[{"given":"Douglas R.","family":"Maxwell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherry L.","family":"Donahay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Kathy","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Hamburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich C.","family":"Luft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978235515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978235515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978235515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:32:20Z","timestamp":1699363940000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978235515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,5]]}},"alternative-id":["10.1002\/cpt1978235515"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978235515","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}