{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:15:58Z","timestamp":1792192558683,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13731,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:p>To study the mechanism whereby toxic doses of methaqualone cause a bleeding tendency in humans, the effects of methaqualone, diphenhydramine, and the combination of methaqualone plus diphenhydramine on blood platelet function were investigated. Exposure of human platelets in platelet\u2010rich plasma in vitro to final concentrations of methaqualone ranging from 1.1 to 4.5 \u00d7 10<jats:sup>\u22124<\/jats:sup> M resulted in nearly complete inhibition of the secondary phase and significant inhibition of the primary phase of adenosine diphosphate (ADP)\u2010induced aggregation. Both the slope and height of collagen\u2010induced aggregation responses were reduced significantly in vitro by the drug. When methaqualone final concentrations of 1.1, 2.3, and 4.5 \u00d7 10<jats:sup>\u22124<\/jats:sup> M were studied in the presence of diphenhydramine (1.1, 2.3, and 4.5 \u00d7 10<jats:sup>\u22125<\/jats:sup> M, respectively), the degree of inhibition of ADP\u2010induced aggregation was only slightly greater (not significant) than that observed with methaqualone. The platelets of rabbits injected intravenously with methaqualone, 10 mg\/kg, demonstrated a significantly decreased ability to aggregate with ADP and collagen 30 and 60 min after administration of the drug. These results suggest that a drug\u2010induced defect of blood platelet function may play a role in the bleeding associated with methaqualone toxicity.<\/jats:p>","DOI":"10.1002\/cpt1978236685","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T01:57:02Z","timestamp":1451959022000},"page":"685-691","source":"Crossref","is-referenced-by-count":8,"title":["Effects of methaqualone on blood platelet function"],"prefix":"10.1111","volume":"23","author":[{"given":"Donald G.","family":"Mills","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978236685","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978236685","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978236685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:32:22Z","timestamp":1699363942000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978236685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,6]]}},"alternative-id":["10.1002\/cpt1978236685"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978236685","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}