{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:33:21Z","timestamp":1759541601530},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13548,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1978,12]]},"abstract":"<jats:p>In order to evaluate the relationship between aldosterone status and the blood pressure\u2010lowering effect of spironolactone, 38 patients with essential hypertension were treated with spironolactone (400 mg\/day) during one week in hospital on a rigidly sodium\u2010restricted diet. The degree of hyperaldosteronism was assessed by the aldosterone secretory rate after 5 days of salt loading (315 mmol Na<jats:sup>+<\/jats:sup>\/day). The mean arterial pressure decreased 5.6% (range, \u221221 to +8%). When the patients were divided into subgroups with low and normal renin activity, there was no difference in the change in mean arterial pressure (\u22125.0% and \u22126.1%). When the patients were divided into three groups with low, normal, and supranormal aldosterone secretory rates, the last group had a significantly greater fall in blood pressure after the spironolactone than the other groups (\u22121.0, \u22127.1, \u221211.1%). Thus there was a correlation between the aldosterone secretory rate after sodium loading and the blood pressure\u2010lowering effect of spironolactone (r = \u22120.53, p &lt; 0.01). The blood pressure\u2010lowering effect was not related to changes in body weight, kidney function, or plasma electrolytes. Our findings do not provide solid arguments for the view that the blood pressure\u2010lowering effect of high dose spironolactone is due to its antimineralocorticoid activity, but the correlation between the degree of hyperaldosteronism and the blood pressure\u2010lowering effect strongly suggests that aldosterone does play a role in the genesis or maintenance of the hypertension in these patients.<\/jats:p>","DOI":"10.1002\/cpt1978246638","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T02:05:54Z","timestamp":1451959554000},"page":"638-643","source":"Crossref","is-referenced-by-count":9,"title":["Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension"],"prefix":"10.1111","volume":"24","author":[{"given":"H.","family":"Benraad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Drayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Hoefnagels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kloppenborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th.","family":"Benraad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978246638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1978246638","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1978246638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:33:17Z","timestamp":1699363997000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1978246638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1978,12]]}},"alternative-id":["10.1002\/cpt1978246638"],"URL":"https:\/\/doi.org\/10.1002\/cpt1978246638","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,12]]}}}