{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T08:34:15Z","timestamp":1718267655101},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13486,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>Furosemide is frequently used for ascites and causes adverse reactions (AR). In an intensive prospective drug monitoring study of 1,920 patients, 172 (8.9%) had cirrhosis of the liver and received furosemide. Mean age was 53 years, and 66.3% were male; and 87% had alcoholic cirrhosis. Eighty\u2010eight (51.2%) had 221 events that by consensus of the monitoring team and attending physicians were either definitely or probably related to furosemide. No AR was fatal but 24% of patients had severe reactions. Almost all reactions were dose\u2010related (96%). The most common were electrolyte disturbances (23.3% of patients) and volume depletion (14%). Furosemide\u2010induced coma occurred in 20 (11.6%) patients and was more frequent in patients with prior hepatic encephalopathy (p &lt; 0.0005). Higher total doses (p &lt; 0.001), hyperbilirubinemia (p &lt; 0.05), prolonged prothrombin time (p &lt; 0.02), and longer hospital stay (p &lt; 0.001) were associated with higher frequencies of AR to furosemide. The frequency of hypokalemia did not decrease when potassium chloride or potassium\u2010sparing diuretics were added to furosemide therapy. Frequdncy of AR did not correlate with age, sex, renal impairment, serum albumin, transaminase, or alkaline phosphatase.<\/jats:p>","DOI":"10.1002\/cpt1979252154","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T02:00:28Z","timestamp":1451959228000},"page":"154-160","source":"Crossref","is-referenced-by-count":26,"title":["Furosemide\u2010induced adverse reactions in cirrhosis of the liver"],"prefix":"10.1111","volume":"25","author":[{"given":"Claudio A.","family":"Naranjo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Pontigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Valdenegro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usoa","family":"Busto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1979252154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1979252154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1979252154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:31:57Z","timestamp":1699363917000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1979252154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1002\/cpt1979252154"],"URL":"https:\/\/doi.org\/10.1002\/cpt1979252154","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}