{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:53:06Z","timestamp":1759693986758},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":13213,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharma and Therapeutics"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:p>The effects of allopurinol on the plasma clearance and metabolism of theophylline in man were investigated under single\u2010dose and multiple\u2010dosing conditions. No change in theophylline clearance was found with the concomitant use of allopurinol but 1\u2010methylxanthine (1MX), a theophylline metabolite not previously described in man, was detected in urine during control and allopurinol treatment phases under both single\u2010 and multiple\u2010dosing conditions. 1MX excretion increased at the expense of 1\u2010methyluric acid (IMU) during the allopurinol treatment phase. It is proposed that the secondary biotransformation of 1MX to IMU is mediated by xanthine oxidase.<\/jats:p>","DOI":"10.1002\/cpt1979265660","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T02:04:59Z","timestamp":1451959499000},"page":"660-667","source":"Crossref","is-referenced-by-count":85,"title":["Effects of allopurinol on theophylline metabolism and clearance"],"prefix":"10.1111","volume":"26","author":[{"given":"John J.","family":"Grygiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindon M. H.","family":"Wing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald J.","family":"Birkett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"container-title":["Clinical Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1979265660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcpt1979265660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpt1979265660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:31:18Z","timestamp":1699363878000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1002\/cpt1979265660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1979,11]]}},"alternative-id":["10.1002\/cpt1979265660"],"URL":"https:\/\/doi.org\/10.1002\/cpt1979265660","archive":["Portico"],"relation":{},"ISSN":["0009-9236","1532-6535"],"issn-type":[{"value":"0009-9236","type":"print"},{"value":"1532-6535","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,11]]}}}