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The aim of this study will be to determine the effects of a virtual live exercise training intervention on muscle health and cardiorespiratory fitness (CRF) variables in a pediatric population with CF under ETI therapy. The \u2018FIQMODE\u2019 Study (FIQ for CF in Spanish, or <jats:italic>fibrosis qu\u00edstica<\/jats:italic>; MOD for modulator therapy; and E for exercise) is a two\u2010arm RCT to evaluate the feasibility and efficacy of a novel exercise intervention to improve the muscle health and quality of life (QoL) of children and adolescents with CF under ETI pharmacological therapies. The exercise group will follow a 16\u2010week, supervised, strength\u2010oriented virtual live exercise training intervention. The control group will follow the standard World Health Organization recommendations for physical activity. Primary outcomes will be muscle health (lower and upper limb strength, respiratory muscle strength, lower limb functional mobility, anthropometry, and body composition) and CRF. Secondary outcomes will be clinical history, lung function, inflammatory status, lifestyle and QoL, adherence, and the Mediterranean Diet Quality Index. Participants will complete measures at baseline (pre\u2010intervention), 16 weeks post\u2010intervention, and 8 months follow\u2010up after the intervention. FIQMODE will provide an evidence\u2010informed protocol for exercise\u2010based therapy focused on outcomes reported in a robust RCT that can be applied across children and adolescents with CF under ETI therapy. FIQMODE will support the standardization of CF therapies with ETI together with exercise therapies, which will maximize the usability of exercise in medical applications, improve muscle quality, reduce pulmonary exacerbation, boost pharmacological improvement, and ultimately help improve the lifestyle of children and adolescents with CF.<\/jats:p><jats:p><jats:bold>Trial registration<\/jats:bold>:\u00a0The protocol has been approved by the Ethics Committee of the Universidad Polit\u00e9cnica de Madrid (REF. 20231215) and registered on ClinicalTrials.gov (NCT06322446). This research was funded by the Instituto de Salud Carlos III, which is co\u2010funded by the European Regional Development Fund (PI 23\/00299). The Instituto de Salud Carlos III supported this study through the project agreement \u201cFIQMODE\u201d with the Universidad Polit\u00e9cnica de Madrid (C2311600157). \u00a9 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC.<\/jats:p>","DOI":"10.1002\/cpz1.70202","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T16:23:26Z","timestamp":1758212606000},"source":"Crossref","is-referenced-by-count":0,"title":["Strength\u2010Oriented Virtual Exercise Training Intervention in Children and Adolescents with Cystic Fibrosis Under CFTR Modulators (the FIQMODE Study): Study Protocol for a Randomized Controlled Trial"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-1722","authenticated-orcid":false,"given":"Lisset","family":"Pantoja\u2010Ar\u00e9valo","sequence":"first","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-9799","authenticated-orcid":false,"given":"Thomas","family":"Yvert","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1073-7298","authenticated-orcid":false,"given":"Tamara","family":"Iturriaga","sequence":"additional","affiliation":[{"name":"ESBIDA Research Group, Department of Sports Sciences, Faculty of Medicine, Health and Sports Universidad Europea de Madrid, Villaviciosa de Od\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-8393","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Sanz\u2010Santiago","sequence":"additional","affiliation":[{"name":"Pneumology Unit Hospital Universitario Infantil Ni\u00f1o Jes\u00fas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4835-5367","authenticated-orcid":false,"given":"Olga","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"ESBIDA Research Group, Department of Sports Sciences, Faculty of Medicine, Health and Sports Universidad Europea de Madrid, Villaviciosa de Od\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-5268","authenticated-orcid":false,"given":"Carlos","family":"Quesada\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"ImFINE Research Group, Department of Health and Human Performance Universidad Polit\u00e9cnica de Madrid  Madrid Spain"},{"name":"Department of Applied Mathematics, Faculty of Computer Systems Engineering Universidad Polit\u00e9cnica de Madrid  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2707-3037","authenticated-orcid":false,"given":"Ana","family":"Morales\u2010Tirado","sequence":"additional","affiliation":[{"name":"Pediatric Service Unit, Ram\u00f3n y Cajal Institute for Health Research IRYCIS Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-8217","authenticated-orcid":false,"given":"Catalina","family":"Santiago\u2010Dorrego","sequence":"additional","affiliation":[{"name":"ESBIDA Research Group, Department of Rehabilitation. 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