{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:25:38Z","timestamp":1789079138467,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Protocols"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Unresectable pancreatic cancer (PC) is characterized by a high prevalence of sarcopenia and cachexia, which negatively impact survival, treatment toxicity, and quality of life (QoL). Currently, evidence evaluating exercise programs in this vulnerable population is limited.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : This prospective, two\u2010arm randomized controlled trial (RCT) will recruit patients with unresectable PC undergoing chemotherapy. Participants will be randomized (1:1) to an intervention group (hypertrophy\u2010oriented resistance training twice weekly) or a control group (standard care).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion<\/jats:bold>\n                    : The primary outcome is the change in total lean body mass (assessed by DXA) at Week 12. Secondary outcomes include maximal strength, peak power, cardiorespiratory capacity, and patient\u2010reported measures. The HY\u2010PANC protocol presents a replicable resistance training intervention designed specifically for advanced PC.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration<\/jats:bold>\n                    : The protocol has been submitted for review and approval by the Clinical Research Ethics Committee of the University Hospital of Getafe and registered on ClinicalTrials.com (NCT07470268). \u00a9 2026 The Author(s).\n                    <jats:italic>Current Protocols<\/jats:italic>\n                    published by Wiley Periodicals LLC.\n                  <\/jats:p>\n                  <jats:p>This article was corrected on 23 July 2026. See the end of the full text for details.<\/jats:p>","DOI":"10.1002\/cpz1.70410","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:22:02Z","timestamp":1784222522000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of Hypertrophy\u2010Oriented Resistance Training on Muscle Mass and Quality of Life in Patients with Unresectable Pancreatic Cancer (HY\u2010PANC): Study Protocol for a Randomized Controlled Trial"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8647-5619","authenticated-orcid":false,"given":"Pablo","family":"Braceras Arias","sequence":"first","affiliation":[{"name":"Department of Sports Sciences, Faculty of Medicine, Health and Sports Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Burgos Postigo","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences, Faculty of Medicine, Health and Sports Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-1369","authenticated-orcid":false,"given":"Lidia","family":"B. Alejo","sequence":"additional","affiliation":[{"name":"Department of Sports Sciences, Faculty of Medicine, Health and Sports Universidad Europea de Madrid  Madrid Spain"},{"name":"Research Institute of the Hospital 12 de Octubre (\u2018imas12\u2019)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181915670"},{"key":"e_1_2_8_3_1","volume-title":"StatPearls [Internet]","author":"Ardeljan A. 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