{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:23:36Z","timestamp":1766269416047,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARIMINUM ODONTOLOGICA SRL, ARDEC ACADEMY"},{"name":"TECNOSS SRL GIAVENO ITALY"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to evaluate possible differences in the assessment of bone formation between histological and micro\u2010computed tomography (CT) analyses in maxillary sinuses augmented with a xenograft with similar density and mineral content of bone. A collagen membrane was placed subjacent the elevated sinus mucosa at the test sites of 18 rabbits, and the elevated spaces were filled with xenograft. The antrostomy was covered with collagen membranes, bilaterally. Six rabbits per group were sacrificed after 2, 4, and 8\u00a0weeks of healing. Biopsies were retrieved and scanned in a high\u2010resolution micro\u2010CT at two different gray thresholds. Histological assessments were subsequently performed. At the histological analyses, bone increased over time, from 7.5\u00a0\u00b1\u00a02.4% to 27.0\u00a0\u00b1\u00a05.3%, between 2 and 8\u00a0weeks of healing. The highest content of bone was found close to the sinus bone walls, whereas the middle regions contained lower amounts. At the micro\u2010CT analyses, discrepancies were found in bone content percentages compared with the histological analyses, especially after 2\u00a0weeks of healing and within the middle regions of the sinus, in which new bone was ~15\u201322% at the micro\u2010CT analyses and only 1.6% at the histological evaluation. The outcomes of a micro\u2010CT analysis performed in an early phase of healing may be altered when a resorbable bone substitute with similar density and mineral content of bone is applied.<\/jats:p>","DOI":"10.1002\/cre2.146","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T09:43:08Z","timestamp":1542966188000},"page":"284-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Histological and micro\u2010computed tomography evaluations of newly formed bone after maxillary sinus augmentation using a xenograft with similar density and mineral content of bone: An experimental study in rabbits"],"prefix":"10.1002","volume":"4","author":[{"given":"Takahisa","family":"Iida","sequence":"first","affiliation":[{"name":"Department of Oral Implantology Osaka Dental University  Hirakata Japan"},{"name":"ARDEC Academy Ariminum Odontologica  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick Ricardo","family":"Silva","sequence":"additional","affiliation":[{"name":"Depto CTBMF e Periodontia FORP\u2010USP\u2010Faculty of Ribeir\u00e3o Preto (SP)  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6496-6846","authenticated-orcid":false,"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Center for Dental Medicine University of Zurich  Zurich Switzerland"},{"name":"Department of Periodontology University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-5222","authenticated-orcid":false,"given":"Karol Al\u00ed","family":"Apaza Alccayhuaman","sequence":"additional","affiliation":[{"name":"ARDEC Academy Ariminum Odontologica  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Academy Ariminum Odontologica  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel P.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Depto CTBMF e Periodontia FORP\u2010USP\u2010Faculty of Ribeir\u00e3o Preto (SP)  Ribeir\u00e3o Preto 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