{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:45Z","timestamp":1790023365191,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T00:00:00Z","timestamp":1561852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College of Dentistry Research Centre"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A systematic review and meta\u2010analysis was performed to understand the efficacy of xenogeneic collagen matrix (CMX) compared with connective tissue graft (CTG) for the treatment of multiple adjacent gingival recessions (MAGRs). A literature search was performed for published randomized controlled trials in adult patients (\u226518\u00a0years old) with Multiple Adjacent Miller class I and II gingival recessions (MAGRs). The assessments included recession depth, Recession width, complete root coverage, mean root coverage, probing depth, clinical attachment level, and keratinized tissue width. Pooled data were analyzed using fixed\u2010 and random\u2010effects models, and Forest plots were constructed. Heterogeneity within studies was calculated to assess publication bias. Four randomized controlled trials were included based on the eligibility criteria. Although the recession depth, complete root coverage, and mean root coverage were significantly lower with CMX (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.017 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, respectively), there was no statistically significant difference in the Recession width between CMX and CTG (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.203). CMX showed significantly lower Probing Depth than CTG (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.023); however, no significant difference in clinical attachment level (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.060) and keratinized tissue width (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.052) was observed between the groups. Owing to the heterogeneity in the included studies, firm conclusions cannot be drawn regarding the noninferiority of CMX compared with CTG. Long\u2010term studies are therefore needed to conclusively establish the relative efficacy of CMX in MAGR.<\/jats:p>","DOI":"10.1002\/cre2.210","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:19:53Z","timestamp":1561940393000},"page":"566-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Xenogeneic collagen matrix versus connective tissue graft for the treatment of multiple gingival recessions: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-1914","authenticated-orcid":false,"given":"Mohammed A.","family":"AlSarhan","sequence":"first","affiliation":[{"name":"Department of Periodontics &amp; Community Dentistry, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham","family":"Al Jasser","sequence":"additional","affiliation":[{"name":"Department of Periodontics &amp; Community Dentistry, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Abdullah","family":"Tarish","sequence":"additional","affiliation":[{"name":"Department of Preventive Dental Science ELM University  Riyadh Saudi Arabia"},{"name":"Capital Health Region Ministry of Health  Kuwait Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas I.","family":"AlHuzaimi","sequence":"additional","affiliation":[{"name":"College of Dentistry King Saud University  Riyadh Saudi Arabia"},{"name":"Medical Services Ministry of Interior  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamad","family":"Alzoman","sequence":"additional","affiliation":[{"name":"Department of Periodontics &amp; Community Dentistry, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,30]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"E304","article-title":"A comparative study of the long term results of root coverage with connective tissue graft or enamel matrix protein: 24\u2010month results","volume":"14","author":"Abolfazli N.","year":"2009","journal-title":"Medicina Oral, Patolog\u00eda Oral Y Cirug\u00eda Bucal"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12112"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12333"},{"issue":"5","key":"e_1_2_8_6_1","article-title":"Surgical reconstruction of the interdental papilla","volume":"18","author":"Azzi R.","year":"1998","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12750"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12182"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080565"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110215"},{"key":"e_1_2_8_11_1","first-page":"34","article-title":"Coronally advanced flap with and without a xenogenic collagen matrix in the treatment of multiple recessions: A randomized controlled clinical study","author":"Cardaropoli D.","year":"2014","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150676"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0026256"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12948"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/6\/1\/015010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12172"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"issue":"3","key":"e_1_2_8_18_1","article-title":"A single\u2010incision technique to harvest subepithelial connective tissue grafts from the palate","volume":"19","author":"H\u00fcrzeler M. 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