{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:26:23Z","timestamp":1784751983041,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Neonatal thrush, also called oral candidiasis, is commonly a clinical diagnosis based on white patches on oral mucosal surfaces. <jats:styled-content style=\"fixed-case\"><jats:italic>Candida albicans<\/jats:italic><\/jats:styled-content> is often associated with it. This clinical study aimed to investigate the presence of <jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic><\/jats:styled-content> among newborns with or without clinical findings of candidiasis on oral mucosa. Another aim was to investigate how thrush responded to current therapy by acidic liquids such as lingonberry or lemon juice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Swipe samples were collected from 32 healthy, full\u2010term infants younger than 12 months with or without white patches on oral mucosa. Clinical diagnosis of thrush was made by a community nurse based on thick and yellowish white patches. The routine therapy was oral lingonberry or lemon juice or soda water. Disappearing of patches was controlled by a phone call about 2 weeks after the baseline. Both parents and nurses gave background factors by filling a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One (3%) infant without clinical signs was diagnosed with <jats:styled-content style=\"fixed-case\"><jats:italic>Candida parapsilosis<\/jats:italic><\/jats:styled-content>, none with <jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic><\/jats:styled-content>. Thrush resembling candidiasis was diagnosed clinically in four (12.5%) children. Three out of four parents reported persisting findings after 2 weeks. Only the maternal mastitis and use of antibiotics were significantly associated with thrush (<jats:italic>p<\/jats:italic> = .001). <jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic>. <jats:italic>albicans<\/jats:italic><\/jats:styled-content> was not discovered from babies with clinical thrush.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aetiology of the white patches remained unclear. The current way of treating them with acidic liquids is not efficient. Additional studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.213","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T01:09:32Z","timestamp":1563757772000},"page":"580-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neonatal thrush of newborns: Oral candidiasis?"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-2363","authenticated-orcid":false,"given":"Anne","family":"Vainionp\u00e4\u00e4","sequence":"first","affiliation":[{"name":"Research Unit of Oral Health Sciences University of Oulu  Oulu Finland"},{"name":"Department of Special Dentistry Unit Oral Health Care of City of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Tuomi","sequence":"additional","affiliation":[{"name":"Research Unit of Oral Health Sciences University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kantola","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuokko","family":"Anttonen","sequence":"additional","affiliation":[{"name":"Research Unit of Oral Health Sciences University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu University Hospital and University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30523-2"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"234","article-title":"Moniliasis in pediatrics","volume":"94","author":"Dobias B.","year":"1957","journal-title":"The American Journal of Diseases of Children"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12100"},{"issue":"11","key":"e_1_2_7_5_1","first-page":"891","article-title":"The effect of nystatin (mycostatin) on neonatal candidiasis (thrush): A method of eradicating thrush from hospital nurseries","volume":"79","author":"Harris L. J.","year":"1958","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-11-79"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)30700-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182863a1c"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12355"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:24:05Z","timestamp":1694237045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,21]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/cre2.213"],"URL":"https:\/\/doi.org\/10.1002\/cre2.213","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,21]]},"assertion":[{"value":"2019-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}