{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:51:36Z","timestamp":1782787896798,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Conventional disinfectants and medicaments have not been able to achieve and maintain sterilization of root canals. The purpose of the study was to evaluate the antibacterial efficacy of 3.8% silver diamine fluoride (SDF) in comparison with 2% chlorhexidine (CHX) against <jats:italic>Enterococcus faecalis<\/jats:italic> biofilm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Extracted human teeth were used to make 70 dentin discs that were then inoculated with <jats:italic>E. faecalis<\/jats:italic> to generate a 3\u2010week\u2010old biofilm model. The discs were subjected to treatment with 3.8% SDF, 2% CHX, sodium hypochlorite (NaOCl), or saline for 10 min. After exposure, the dentin discs were examined with a confocal laser scanning microscope to verify the percentage of live versus dead cells within the biofilm. Univariate one\u2010way analysis of variance and Tukey\u2010honestly significant difference post hoc analysis (<jats:italic>p<\/jats:italic> &lt; .05) were performed to detect significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>The NaOCl group showed the greatest percentage of dead cells (62.26%) among all groups (<jats:italic>p<\/jats:italic> &lt; .05). The SDF group showed a significantly higher percentage of dead cells (57.39%) than the 2% CHX and saline groups (<jats:italic>p<\/jats:italic> &lt; .05). SDF possessed higher antimicrobial activity than 2% CHX against <jats:italic>E. faecalis<\/jats:italic> biofilms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.222","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:35:55Z","timestamp":1563341755000},"page":"551-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antibacterial efficacy of silver diamine fluoride as a root canal irrigant"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-7757","authenticated-orcid":false,"given":"Ebtissam M.","family":"Al\u2010Madi","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, College of Dentistry King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar A.","family":"Al\u2010Jamie","sequence":"additional","affiliation":[{"name":"Department of Dentistry Ministry of 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