{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:24:04Z","timestamp":1783207444693,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011198","name":"FP7 Research Potential of Convergence Regions","doi-asserted-by":"publisher","award":["800\u201020160461"],"award-info":[{"award-number":["800\u201020160461"]}],"id":[{"id":"10.13039\/100011198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011198","name":"FP7 Research Potential of Convergence Regions","doi-asserted-by":"publisher","award":["860\u201020160116"],"award-info":[{"award-number":["860\u201020160116"]}],"id":[{"id":"10.13039\/100011198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to prospectively evaluate the clinical features of chemotherapy\u2010induced oral mucositis (CIOM) in adult patients with acute leukemia and the aggravating factors for such symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects<\/jats:title><jats:p>Thirty\u2010seven prospective patients aged \u226519 years with acute leukemia undergoing chemotherapy were enrolled. Oral and clinical investigations were performed at baseline and on Day 14 after starting chemotherapy. The presence and severity of cancer\u2010induced oral mucositis were demonstrated using the World Health Organization (WHO) scoring system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On Day 14, we found that oral mucositis had developed in eight patients (21.6%). Hematopoietic stem cell transplantation (HSCT) in patients was a predictor of increased WHO scores (<jats:italic>\u03b2<\/jats:italic> = 1.937, <jats:italic>p<\/jats:italic> &lt; .001). Regarding oral sites, ventral tongue (<jats:italic>\u03b2<\/jats:italic> = 1.670), soft palate (<jats:italic>\u03b2<\/jats:italic> = 1.242), and buccal mucosa (<jats:italic>\u03b2<\/jats:italic> = 0.593) were predictors for increased scores. In addition, the increase in WHO scores was positively correlated with the number of oral lesions (<jats:italic>r<\/jats:italic> = .521), the difficulty in eating (<jats:italic>r<\/jats:italic> = .250), and the overall oral health (<jats:italic>r<\/jats:italic> = .534; all <jats:italic>p<\/jats:italic> &lt; .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The main factors affecting the severity of CIOM symptoms were the treatment with HSCT and the location of oral lesions. The incidence of CIOM and WHO scores were not significantly different between the subgroups of disease. Our findings will help clinicians investigate the oral findings after chemotherapy in adult patients with acute leukemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.253","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T07:03:42Z","timestamp":1575961422000},"page":"90-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prospective evaluation of clinical symptoms of chemotherapy\u2010induced oral mucositis in adult patients with acute leukemia: A preliminary study"],"prefix":"10.1002","volume":"6","author":[{"given":"Yeon\u2010Hee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Orofacial Pain and Oral Medicine Kyung Hee University Dental Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshik","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngnim","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Microbiology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis, Dental Research Institute Seoul National University Dental Hospital, Seoul National University School of Dentistry  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"Barbui T. 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