{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:13:26Z","timestamp":1792325606170,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study's aim was to assess the clinical outcome 6 and 12\u2009months after a nonsurgical treatment of peri\u2010implantitis per se or in conjunction with a combination of local antiseptic and anti\u2010inflammatory treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Included were 69 patients with periodontitis, with 106 implants, diagnosed with peri\u2010implantitis. Peri\u2010implantitis was defined as radiographic bone loss \u22653\u2009mm, probing depth (PD)\u2009\u2265\u20096\u2009mm, with bleeding on probing. Group M peri\u2010implantitis was treated with ultrasonic debridement and soft tissue curettage. Group P had additional implant surface treatment with rotatory hand piece composed of chitosan bristle, soft tissue curettage combined with application of 0.95% hypochlorite and 1 mg minocycline HCl.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 6 months, both groups demonstrated significant reduction of mean plaque index, PD, and clinical attachment level (0.71\u2009\u00b1\u20090.57, 0.81\u2009\u00b1\u20090.55; 4.77\u2009\u00b1 0.73\u2009mm, 4.42\u2009\u00b1\u20090.5\u2009mm; 5.03\u2009\u00b1\u20090.86\u2009mm, 5.13\u2009\u00b1\u20090.73\u2009mm; respectively) and bleeding on probing. After 6 and 12\u2009months, group P showed significantly better PD results compared to group M. The bleeding was significantly less in group P after 12\u2009months (15.3%\u2009\u00b1\u20096.2, 25.1%\u2009\u00b1\u20098.2, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjunctive treatment with local antiseptic and anti\u2010inflammatories during mechanical phase was positively associated with inflammation reduction and connective tissue reattachment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.286","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T04:02:25Z","timestamp":1584504145000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A nonsurgical treatment of peri\u2010implantitis using mechanic, antiseptic and anti\u2010inflammatory treatment: 1 year follow\u2010up"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-7961","authenticated-orcid":false,"given":"Yaniv","family":"Mayer","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Graduate Dentistry Rambam Health Care Campus  Haifa Israel"},{"name":"Periocenter Ltd.  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofir","family":"Ginesin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Graduate Dentistry Rambam Health Care Campus  Haifa Israel"},{"name":"Periocenter Ltd.  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Graduate Dentistry Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514551754"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130563"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13095"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39612"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13456"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517740560"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13127"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2014suppl.g5.3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12817"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.2.82"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000838"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13441"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00688.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.09.012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12240"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-16-00147"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1563\/aaid-joi-D-17-00261"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.7343"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02570.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02208.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/487903"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02186.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030402.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.5940"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-02943-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000593"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2276-y"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-018-0135-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12160"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00919.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070347"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12612"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01377.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13372"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2016.7313"},{"key":"e_1_2_8_39_1","article-title":"Risk of superinfection in peri\u2010implantitis after systemic broad Spectrum antibiotics","author":"Verdugo F.","year":"2017","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_8_40_1","first-page":"111","article-title":"The nonantimicrobial properties of tetracycline for the treatment of periodontal disease","author":"Vernillo A. 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