{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:32:55Z","timestamp":1785382375531,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To assess the differences in the frequency of clinical signs of temporomandibular disorder (TMD) pain and mandibular function impairment between mandibular advancement device (MAD) and nasal continuous positive airway pressure (nCPAP) therapies in obstructive sleep apnea (OSA) patients at baseline and after 6 month of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study concerns a secondary analysis of a randomized placebo\u2010controlled trial in which different treatment effects of an objectively titrated MAD were compared with those of nCPAP and an intra\u2010oral placebo appliance in a parallel design. Sixty\u2010four mild to severe OSA patients (52.0\u2009\u00b1\u20099.6\u2009years) were randomly assigned to these three groups. All patients underwent a shortened functional examination of their masticatory system at baseline and after 6 months to establish the presence of clinical signs of TMD pain. Mandibular function impairment was assessed with a questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical signs of TMD pain were only rarely present at baseline and therapy evaluation. No significant differences were found between the three groups in the (low) frequency of clinical signs of TMD pain at both time points (<jats:italic>p<\/jats:italic> = .401\u2013.176). In addition, the (low) scores of mandibular function impairment did not differ between the three groups either, neither at baseline (<jats:italic>p<\/jats:italic> = .744) nor after 6 months (<jats:italic>p<\/jats:italic> = .359).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A low frequency of clinical signs of TMD pain in mild to severe OSA patients was found after 6 months, regardless of treatment with MAD or nCPAP. In addition, no difference in mandibular function impairment was observed between the different treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.288","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T09:41:32Z","timestamp":1585993292000},"page":"400-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: A randomized, placebo\u2010controlled trial on temporomandibular side\u2010effects"],"prefix":"10.1002","volume":"6","author":[{"given":"Maria","family":"Nikolopoulou","sequence":"first","affiliation":[{"name":"Department of Orofacial Pain and Dysfunction, Academic Centre of Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-7897","authenticated-orcid":false,"given":"Ghizlane","family":"Aarab","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Dysfunction, Academic Centre of Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-0441","authenticated-orcid":false,"given":"Jari","family":"Ahlberg","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Hamburger","sequence":"additional","affiliation":[{"name":"Amsterdam Sleep Centre, Boerhaave Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"de Lange","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Amsterdam University Medical Centre and Academic Centre for Dentistry Amsterdam (ACTA)  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-7640","authenticated-orcid":false,"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Dysfunction, Academic Centre of Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0298-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000319595"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324580"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201503-0647UP"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.01.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/22.1.53"},{"key":"e_1_2_9_9_1","first-page":"339","article-title":"Prevalence of temporomandibular disorders in obstructive sleep apnea patients referred for oral appliance therapy","volume":"23","author":"Cunali P. 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