{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:38:17Z","timestamp":1783125497198,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the course of pain intensity and frequency related to temporomandibular disorders (TMDs) 15\u2009years (range 5\u201321\u2009years) after having received TMD treatment as adolescents due to frequent (at least once a week) TMD pain in two controlled trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the first trial, subjects (<jats:italic>n<\/jats:italic> = 122) were randomly allocated to either information only, received in a control condition (Co), or information and an occlusal appliance (OA) versus relaxation therapy (RT). In the second trial, including 64 subjects, nonresponders to OA or RT were subsequently allocated to the alternate treatment (ST). All study participants having completed the trials (<jats:italic>n<\/jats:italic> = 167) were invited to a long\u2010term follow\u2010up evaluations, with a response rate of 69.5% (<jats:italic>n<\/jats:italic> = 116). Patient\u2010reported outcomes of TMD\u2010related frequency and intensity were appraised relative to baseline data and short\u2010term outcomes as observed in the two trials by use of general linear mixed model and generalized estimation equation statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significantly higher proportion of participants treated with OA and in the combined RT\/Co condition than those in the ST group, reported a frequency level of TMD pain less than once week at post\u2010treatment and the long\u2010term follow\u2010up. Adolescents treated with OA showed significantly lower TMD pain intensity levels post\u2010treatment than those in the other two treatment conditions. While no difference between the OA and the RT\/Co conditions was found in the long\u2010term follow\u2010up, participants in these two conditions were significantly more improved than those in the ST group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adolescents treated with an OA clearly showed better outcome with regard to intensity and frequency in a long\u2010term follow\u2010up of TMD pain than those treated with RT and ST for nonresponders. These latter individuals need special clinical attention and more effective supplementary treatment methods to be developed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.289","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T07:58:50Z","timestamp":1587196730000},"page":"407-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The course of pain intensity and frequency of adolescents treated because of temporomandibular disorders: A long\u2010term follow\u2010up"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-8546","authenticated-orcid":false,"given":"Kerstin","family":"Wahlund","sequence":"first","affiliation":[{"name":"Department of Stomatognathic Physiology Kalmar County Hospital  Kalmar Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Larsson","sequence":"additional","affiliation":[{"name":"Regional Center for Child and Youth Mental Health and Child Welfare \u2013 Central Norway Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD002778","article-title":"Stabilisation splint therapy for temporomandibular pain dysfunction syndrome","volume":"1","author":"Al\u2010Ani M. Z.","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350701408206"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350801978660"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016350903431118"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.09.005"},{"key":"e_1_2_7_7_1","first-page":"301","article-title":"Research diagnostic criteria for temporomandibular disorders: Review, criteria, examination and specifications, critique","volume":"6","author":"Dworkin S. F.","year":"1992","journal-title":"Journal of Craniomandibular Disorders"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/000163501300035788"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350410010063"},{"key":"e_1_2_7_10_1","first-page":"13","article-title":"Self\u2010perceived effects of occlusal appliance therapy on TMD patients: An eight\u2010year follow\u2010up","volume":"37","author":"Erixon C. L.","year":"2013","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2016.1191086"},{"key":"e_1_2_7_12_1","first-page":"381","article-title":"Pain\u2010related impairment and health care utilization in children and adolescents: A comparison of orofacial pain with abdominal pain, back pain, and headache","volume":"37","author":"Hirsch C.","year":"2006","journal-title":"Quintessence International"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0265-5"},{"key":"e_1_2_7_14_1","volume-title":"IBM SPSS statistics for windows, version 25.0","author":"IBM Corp. Released","year":"2017"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.05138.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030401"},{"key":"e_1_2_7_17_1","first-page":"218","article-title":"Psychosocial functioning and dental factors in adolescents with temporomandibular disorders: A case\u2013control study","volume":"15","author":"List T.","year":"2001","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_18_1","first-page":"9","article-title":"TMD in children and adolescents: Prevalence of pain, gender differences, and perceived treatment need","volume":"13","author":"List T.","year":"1999","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2011.02239.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350510019739"},{"key":"e_1_2_7_21_1","first-page":"115","article-title":"Impact of temporomandibular disorder pain in adolescents: Differences by age and gender","volume":"23","author":"Nilsson I. M.","year":"2009","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_22_1","first-page":"144","article-title":"Prevalence of temporomandibular pain and subsequent dental treatment in Swedish adolescents","volume":"19","author":"Nilsson I. M.","year":"2005","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_23_1","first-page":"138","article-title":"The reliability and validity of self\u2010reported temporomandibular disorder pain in adolescents","volume":"20","author":"Nilsson I. M.","year":"2006","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_24_1","first-page":"127","article-title":"Incidence and temporal patterns of temporomandibular disorder pain among Swedish adolescents","volume":"21","author":"Nilsson I. M.","year":"2007","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513496255"},{"key":"e_1_2_7_26_1","first-page":"107","article-title":"Adolescents with temporomandibular disorder pain\u2010the living with TMD pain phenomenon","volume":"25","author":"Nilsson I. M.","year":"2011","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1450"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12275"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1241"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-004-0265-4"},{"key":"e_1_2_7_31_1","first-page":"210","article-title":"Treatment outcome in patients with craniomandibular disorders of muscular origin: A 7\u2010year follow\u2010up","volume":"12","author":"Vallon D.","year":"1998","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2017.1394490"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310003891"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1285"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016359609003548"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcre2.289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:51:43Z","timestamp":1693932703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,18]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cre2.289"],"URL":"https:\/\/doi.org\/10.1002\/cre2.289","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,18]]},"assertion":[{"value":"2019-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}