{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:03:58Z","timestamp":1789736638974,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["IRCT2013011611976N2"],"award-info":[{"award-number":["IRCT2013011611976N2"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology which is known as a premalignant disease. A complete cure has not been found for this condition. Mycophenolate mofetil (MMF) is a new drug that seems to be effective in improving OLP lesions. But there are no studies on the efficacy of mucoadhesive form of MMF in ulcerative OLP. Therefore, this study was performed to determine the therapeutic effect of MMF mucoadhesive on OLP lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Twenty\u2010seven patients with OLP, were enrolled in two groups. All the patients were instructed to place the MMF 2% mucoadhesive on the lesion twice daily for 4\u2009weeks. Lesion size was measured by a sterile digital caulis (mm) and the severity of burning sensation and pain by visual analogue scale (VAS; cm) at baseline and weekly follow\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in burning sensation and lesion size at Weeks 1, 2, and 3 in both groups. In Group A, at Week 4, there was significant reduction in pain and burning sensation and lesion size on both sides (<jats:italic>p<\/jats:italic> = .048, .012). The difference in lesion size on control sides was not significant. In Group B, at Week 4, there was significant reduction in pain and burning sensation and lesion size (<jats:italic>p<\/jats:italic> = .004). No side effects were reported by the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the results, 2% MMF mucoadhesive was effective in decreasing burning sensation and pain severity and ulcer size of ulcerative OLP and the effect was time\u2010dependent.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.302","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T10:00:57Z","timestamp":1593252057000},"page":"506-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Treatment of oral lichen planus with mucoadhesive mycophenolate mofetil patch: A randomized clinical trial"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-0098","authenticated-orcid":false,"given":"Negin","family":"Samiee","sequence":"first","affiliation":[{"name":"Post Graduate Student of Oral and Maxillofacial Medicine, Oral and Maxillofacial Medicine Department Mashhad Dental Faculty  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Taghavi Zenuz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumeh","family":"Mehdipour","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"29","article-title":"Efficacy of Elaeagnus angustifolia topical gel in the treatment of symptomatic Oral lichen planus","volume":"4","author":"Beigom Taheri J.","year":"2010","journal-title":"Journal of Dental Research Dental Clinics Dental Prospects"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.11.1447"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1536"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01832.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02111-X"},{"key":"e_1_2_9_8_1","first-page":"104","volume-title":"Burket's oral medicine","author":"Glick M.","year":"2015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.11.001"},{"key":"e_1_2_9_10_1","article-title":"Interventions for treating oral lichen planus: Corticosteroid therapies","volume":"2","author":"Lodi G.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.02.013"},{"issue":"35","key":"e_1_2_9_12_1","first-page":"46","article-title":"Efficacy of oral metronidazole in patients with generalized cutaneous lichen planus","volume":"9","author":"Nazemi T. 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