{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:21:55Z","timestamp":1780618915354,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To date, the best treatment for Medication Related Osteonecrosis of the jaw (MRONJ) is controversial. Recent studies suggest different therapies, considering the stage of MRONJ; however, sometimes patients, although with remarkable extension of disease, cannot undergo surgery. The purpose of present preliminary study was to evaluate the efficacy of conservative non\u2010surgical treatment of MRONJ lesions in a cohort of patients ineligible for surgery or refusing any surgical treatment for stage II and III of MRONJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Patients with MRONJ (staging II or III) ineligible for surgical treatment were selected for a retrospective study. A conservative non\u2010surgical therapy (antibiotics and antiseptic) was administered for 1\u2009year. Five scheduled checks were performed to assess changes in signs and symptoms during the observational period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our observation was carried out on 12 patients. Improvement of signs and symptoms of disease were observed in population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that non\u2010surgical treatment may be a valid therapeutic option in patients ineligible for surgery. The sample size is small, further studies should be carried out to satisfy the aim of a conservative non\u2010surgical treatment protocol establishment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.303","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T12:48:37Z","timestamp":1593694117000},"page":"512-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Conservative non\u2010surgical management in medication related osteonecrosis of the jaw: A retrospective study"],"prefix":"10.1002","volume":"6","author":[{"given":"Massimo","family":"Albanese","sequence":"first","affiliation":[{"name":"Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Zotti","sequence":"additional","affiliation":[{"name":"Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-8041","authenticated-orcid":false,"given":"Giorgia","family":"Capocasale","sequence":"additional","affiliation":[{"name":"Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonetti","sequence":"additional","affiliation":[{"name":"independent researcher  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Lonardi","sequence":"additional","affiliation":[{"name":"Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Francesco","family":"Nocini","sequence":"additional","affiliation":[{"name":"Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynecology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"e6944","article-title":"Medication\u2010related osteonecrosis of the jaw: A review","volume":"12","author":"AlDhalaan N. A.","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2012.01903.x"},{"issue":"1","key":"e_1_2_7_4_1","first-page":"e43\u2013e57","article-title":"Analysis of different therapeutic protocols for osteonecrosis of the jaw associated with oral and intravenous bisphosphonates","volume":"22","author":"Berm\u00fadez\u2010Bejarano E. B.","year":"2017","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"issue":"10","key":"e_1_2_7_5_1","first-page":"CD012432","article-title":"Interventions for managing medication\u2010related osteonecrosis of the jaw","volume":"6","author":"Beth\u2010Tasdogan N. H.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4597321"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2016.11.030"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.211"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12489"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-015-0883-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2684924"},{"key":"e_1_2_7_12_1","series-title":"In: StatPearls [Internet].","volume-title":"American society of anesthesiologists classification (ASA Class)","author":"Doyle D. J.","year":"2020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12148"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3147-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2325-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2016.08.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3982540"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.01.008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.07.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.05.003"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12999"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2012.08.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.11.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0762.178742"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2380084418770662"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.06.004"},{"issue":"4","key":"e_1_2_7_30_1","first-page":"181","article-title":"Bisphosphonate\u2010related osteonecrosis of the jaw (BRONJ) therapy. A critical review","volume":"59","author":"Vescovi P.","year":"2010","journal-title":"Minerva Stomatologica"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcre2.303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T22:18:29Z","timestamp":1693952309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,2]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/cre2.303"],"URL":"https:\/\/doi.org\/10.1002\/cre2.303","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,2]]},"assertion":[{"value":"2020-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}