{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:25:57Z","timestamp":1784298357040,"version":"3.55.0"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically assess the long\u2010term outcome (\u22655\u2009years) of root coverage procedures reported in controlled clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Literature search was performed according to the PRISMA guidelines with the following eligibility criteria: (a) English or German language; (b) controlled (CT) or randomised controlled clinical trials (RCT); (c) root coverage procedure with \u22655\u2009years follow\u2010up; and (d) clinical treatment effect size and\/or patient\u2010related outcome measures (PROMs) reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four CT and 14 RCT with a follow\u2010up of 5\u201320\u2009years fulfilled the eligibility criteria; sample size per study ranged from 8 to 70 patients contributing with 18\u2013149 sites. Coronally advanced flap (CAF) and CAF\u2009+\u2009connective tissue graft (CTG) were the prevalent treatments (i.e., in 24 and 38% of the groups, respectively), while other flap designs and adjuncts (i.e., enamel matrix derivative, bone graft, collagen membrane) were represented only once. For single Miller class I\/II gingival recessions (GR), CAF\u2009+\u2009CTG appeared advantageous compared to other techniques, and provided low residual recession depths (i.e., \u22640.5\u2009mm), and complete root coverage in \u22652\/3 of the patients; similar tendency was observed for multiple GR. No data on Miller class III\/IV GR is available. No meta\u2010analysis was feasible due to lack of similarity in the clinical and methodological characteristics across the trials and observed comparisons of interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CAF\u2009+\u2009CTG appears to be the \u2018gold standard\u2019 technique for the treatment of single and multiple Miller class I\/II GR also in regard to long\u2010term (i.e., \u22655\u2009years of follow\u2010up) treatment outcomes. There is little information regarding the performance, on the long\u2010term, of other techniques and adjuncts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.395","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T01:11:43Z","timestamp":1613005903000},"page":"692-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Root coverage stability: A systematic overview of controlled clinical trials with at least 5\u2009years of follow\u2010up"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7943","authenticated-orcid":false,"given":"Kristina","family":"Bertl","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Odontology University of Malm\u00f6  Malm\u00f6 Sweden"},{"name":"Division of Oral Surgery University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loukia M.","family":"Spineli","sequence":"additional","affiliation":[{"name":"Midwifery Research and Education Unit, Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Mohandis","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Odontology University of Malm\u00f6  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Odontology University of Malm\u00f6  Malm\u00f6 Sweden"},{"name":"Division of Conservative Dentistry and Periodontology University Clinic of Dentistry, Medical University of Vienna  Vienna Austria"},{"name":"Division of Regenerative Dentistry and Periodontology University Clinics of Dental Medicine (CUMD), University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Academy of Cosmetic Dentistry (AACD). 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