{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:23:29Z","timestamp":1781382209557,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005009","name":"Stiftelsen Assar Gabrielssons Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate if patients with temporomandibular disorders (TMD) prior to head and neck cancer (HNC) treatment are at higher risk of developing trismus after oncological treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Eighty\u2010three study patients underwent detailed dental examination prior oncological treatment and 6\u00a0months after radiotherapy completion, including evaluation of temporomandibular jaw function, palpation of the jaw muscles, and measurement of mouth opening capacity. TMD criteria were based on both clinical examination findings and patient\u2010reported symptoms. TMD at baseline was used in regression analysis in order to predict restricted mouth opening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 6\u00a0months follow\u2010up more than a third of the patients (35%) were examined with reduced mouth opening of &gt;20% compared to baseline. A majority of the patients had bilateral tenderness of both the temporal and the masseter muscle. At the 6\u00a0months follow\u2010up, 42% of the study patients reported mouth opening problems. About one\u2010third of the patients suffered from fatigue and stiffness of the jaw as well as pain when mowing the jaw. Two questions from the validated symptom\u2010specific Gothenburg Trismus Questionnaire were found to be related to a statistically significant increased risk of restricted mouth opening after radiotherapy; \u201cDuring the last week, have you felt: Pain on moving the jaw?\u201d (OR [95% CI] 5.9 (1.2\u201329.4) [<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030]) and \u201cDuring the last week, have you felt pain and tenderness in the muscles of mastication?\u201d (OR [95% CI] 5.90 [1.19\u201329.40] [<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TMD is common amongst HNC patients. Patients who suffer from pain in the jaw muscles and pain when moving the jaw before start of treatment are at higher risk of radiation\u2010induced trismus after 6\u00a0months. Clinicians should strive for optimizing the patients pain treatment and oral health before, during, and after radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.511","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T11:31:07Z","timestamp":1636543867000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Temporomandibular disorder as risk factor for radiation\u2010induced trismus in patients with head and neck cancer"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-2477","authenticated-orcid":false,"given":"Nina","family":"Pauli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Fagerberg Mohlin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4406-9216","authenticated-orcid":false,"given":"Christina","family":"Mejersj\u00f6","sequence":"additional","affiliation":[{"name":"Clinic of Orofacial Pain Sahlgrenska Academy and Public Dental Health  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Finizia","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.07.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2005.08.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2994"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.02.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23816"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1610-9"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"1","article-title":"Clinical signs indicative of temporomandibular disorders in adults: Time trends and associated factors","volume":"37","author":"Kohler A. 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