{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:24:09Z","timestamp":1789759449601,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical efficacy of intralesional platelet\u2010rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups showed significant improvement in the clinical parameters (pain and clinical score) \u201c<jats:italic>p<\/jats:italic>\u2009=\u2009.001.\u201d\u00a0Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> registry under the identifier number: NCT03293368.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.550","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T19:21:50Z","timestamp":1645903310000},"page":"707-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy of intralesional injections of platelet\u2010rich plasma in patients with oral lichen planus: A pilot randomized clinical trial"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-6995","authenticated-orcid":false,"given":"AbdelHameed","family":"Hijazi","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheir","family":"Gaafar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.07.032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100529"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03702-w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12388"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.05.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06920.x"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"333","article-title":"Autologous platelet concentrate for post\u2010extraction socket healing: A systematic review","volume":"7","author":"Del Fabbro M.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"issue":"219","key":"e_1_2_9_9_1","first-page":"1","article-title":"Platelet\u2010rich plasma therapy\u2014Future or trend?","volume":"14","author":"Dhillon R. S.","year":"2012","journal-title":"Arthritis Research & Therapy"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00996.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12363"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12633.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812473237"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.076"},{"key":"e_1_2_9_15_1","unstructured":"Lor\u00e9 B. Saraceno R. Poladas G. Fida M. Khoury C. Arcuri C. &Magnato R.(2016).Oral lichen planus: Therapy and phenotype. Giornale Italiano Di Dermatologia e Venereologia: Organo Ufficiale Societa Italiana Di Dermatologia e Sifilografia.http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27982545"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01945.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006899.pub3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6010015"},{"key":"e_1_2_9_19_1","unstructured":"Mostafa R. A. Hosny M. M. Kassem N. M. &Gaafar S. M.(2013).Clinical Evaluation of effectiveness of platelet rich plasma (PRP) versus PRP in combination with bioresorbable bone graft in treatment of periodontal osseous defects in human thesis submitted to the faculty of oral and dental medicine in partial fulfil. Cairo University."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13552"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000186454.07097.bf"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2020.09.008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00605995"},{"issue":"1","key":"e_1_2_9_24_1","first-page":"1","article-title":"Platelet rich plasma a new prospective in treatment of recalcitrant erosive lichen planus\u2014A case report","volume":"3","author":"Shaik S.","year":"2020","journal-title":"International Journal of Research and Reports in Dentistry"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","unstructured":"Sobhy A. 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