{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:18:20Z","timestamp":1771237100588,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH2016251"],"award-info":[{"award-number":["TYH2016251"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH2017251"],"award-info":[{"award-number":["TYH2017251"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["TYH2018229"],"award-info":[{"award-number":["TYH2018229"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["Y1014SL017"],"award-info":[{"award-number":["Y1014SL017"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["Y1014SL018"],"award-info":[{"award-number":["Y1014SL018"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","award":["Y1014SULE1"],"award-info":[{"award-number":["Y1014SULE1"]}],"id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to validate an active matrix metalloproteinase\u00a0(MMP\u20108) point\u2010of\u2010care diagnostic tool in COVID\u201019 patients with periodontal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects, Materials, and Methods<\/jats:title><jats:p>Seventy\u2010two COVID\u201019\u2010positive and 30 COVID\u201019\u2010negative subjects were enrolled in the study. Demographic data were recorded, periodontal examination carried out, and chairside tests run for evaluating the expression of active\u00a0MMP\u20108\u00a0(aMMP\u20108) in the site with maximum periodontal breakdown via gingival crevicular fluid sampling as well as via a mouth rinse\u2010based kit for general disease activity. In COVID\u201019\u2010positive patients, the kits were run again once the patients turned COVID\u201019 negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall (<jats:italic>n<\/jats:italic>\u2009=\u2009102) sensitivity\/specificity of the mouthrinse\u2010based kits to detect periodontal disease was 79.41%\/36.76% and that of site\u2010specific kits was 64.71%\/55.88% while adjusting for age, gender, and smoking status increased the sensitivity and specificity (82.35%\/76.47% and 73.53%\/88.24, respectively). Receiver operating characteristic\u00a0(ROC) analysis for the adjusted model revealed very good area under the ROC curve 0.746\u20130.869 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 0.740\u20130.872 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) (the aMMP\u20108 mouth rinse and site\u2010specific kits, respectively). No statistically significant difference was observed in the distribution of results of aMMP\u20108 mouth rinse test (<jats:italic>p<\/jats:italic>\u2009=\u2009.302) and aMMP\u20108 site\u2010specific test (<jats:italic>p<\/jats:italic>\u2009=\u2009.189) once the subjects recovered from COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study support the aMMP\u20108 point\u2010of\u2010care testing (PoCT) kits as screening tools for periodontitis in COVID\u201019 patients. The overall screening accuracy can be further increased by utilizing adjunctively risk factors of periodontitis. The reported noninvasive, user\u2010friendly, and objective PoCT diagnostic methodology may provide a way of stratifying risk groups, deciding upon referrals, and in the institution of diligent oral hygiene regimens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.589","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:58:34Z","timestamp":1657609114000},"page":"988-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validation of a noninvasive aMMP\u20108 point\u2010of\u2010care diagnostic methodology in COVID\u201019 patients with periodontal disease"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2097-2459","authenticated-orcid":false,"given":"Shipra","family":"Gupta","sequence":"first","affiliation":[{"name":"Unit of Periodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritin","family":"Mohindra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohita","family":"Singla","sequence":"additional","affiliation":[{"name":"Unit of Periodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Khera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Unit of Periodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilminie","family":"Rathnayake","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"},{"name":"Department of Dental Medicine, Division of Periodontology Karolinska Institutet Huddinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pf\u00fctzner","sequence":"additional","affiliation":[{"name":"Clinical Research Department, Diabetes Center and Practice Pf\u00fctzner Science and Health Institute Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5821-5299","authenticated-orcid":false,"given":"Ismo T.","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roop K.","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Kanta","sequence":"additional","affiliation":[{"name":"Department of Virology Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akanksha","family":"Jain","sequence":"additional","affiliation":[{"name":"Unit of Periodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan","family":"Gauba","sequence":"additional","affiliation":[{"name":"Unit of Periodontics, Oral Health Sciences Centre Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kapil","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Virology Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mini P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Virology Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnab","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Virology Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Kajal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Post Graduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Suri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1306396"},{"key":"e_1_2_11_3_1","unstructured":"Centers for Disease Control and Prevention (CDC). (2021). COVID\u201019 guidelines. Accessed April 28 2021. Available online:https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/older-adults.html"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0719"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1997.tb01837.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750121101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb00914.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd17.200247"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520970536"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04111-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00065-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109968"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03310-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.50.31504"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150377"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-015-0413-2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12521"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2020.1858056"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290308.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0713-1"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10080562"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.06.019"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb01249.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics8030067"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130156"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140421"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.1988.tb00318.x"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.262"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12392"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00864"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.11.1292"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13435"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130116"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.9942"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics8040074"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11040711"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9010034"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110276"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2319-2326.1999"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109908"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-020-1747-8"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02263.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10020061"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1995.tb00831.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.69"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13521"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12101"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07679.x"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2021.1976151"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12945"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12939"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753466620951053"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.589","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T14:52:22Z","timestamp":1692802342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/cre2.589"],"URL":"https:\/\/doi.org\/10.1002\/cre2.589","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"2021-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}