{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:27:59Z","timestamp":1785871679538,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008091","name":"University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of this project was to evaluate the role of calcitonin gene\u2010related peptide (CGRP) in the development of arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, we employed somatic mosaic analysis in two different joints by FIV(CGRP) intra\u2010articular inoculation in the knees or temporomandibular joints (TMJ) of young adult male C57\/BL6 mice. FIV(CGRP) is a feline immunodeficiency virus over\u2010expressing full\u2010length CGRP. Joint pathology and function were evaluated at the histopathological and behavioral levels. In addition, CGRP signaling was inhibited by intra\u2010articular inoculation using FIV(CGRP<jats:sub>8\u201037<\/jats:sub>), such that the inhibitory peptide CGRP(8\u201037) was overexpressed 4 weeks after induction of joint inflammation in the TMJ of IL\u20101\u03b2<jats:sup>XAT<\/jats:sup> transgenic mouse model. The mice were evaluated for behavior and killed for evaluation of knee and TMJ pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overexpression of CGRP in the joints of wild\u2010type mice induced the development of joint anomalies, including meniscal hypertrophy and articular pathology, associated with nocifensive behavior. Intriguingly, overexpression of the CGRP(8\u201037) inhibitory peptide in the knee and TMJ of IL\u20101\u03b2<jats:sup>XAT<\/jats:sup> transgenic mice with joint inflammation\u00a0resulted in partial amelioration of the attendant joint pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that CGRP is sufficient and necessary for the development of joint pathology\u00a0and may serve as an intra\u2010articular therapeutic target using gene therapy or monoclonal antibody\u2010based therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.606","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T16:55:48Z","timestamp":1655225748000},"page":"1158-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Calcitonin gene\u2010related peptide: An intra\u2010articular therapeutic target for TMJ disorders"],"prefix":"10.1002","volume":"8","author":[{"given":"Sabine M.","family":"Brouxhon","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Kerry","family":"O'Banion","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Del Monte Institute for Neuroscience University of Rochester School of Medicine &amp; Dentistry  Rochester New York USA"},{"name":"Department of Oral Health Science, College of Dentistry University of Kentucky, and Department of Neurology, University of Rochester School of Medicine &amp; Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Del Monte Institute for Neuroscience University of Rochester School of Medicine &amp; Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-2751","authenticated-orcid":false,"given":"Stephanos","family":"Kyrkanides","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, The Del Monte Institute for Neuroscience University of Rochester School of Medicine &amp; Dentistry  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)00141-W"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.01.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38656"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-7-94"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/13892037113149990057"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23866"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000016660"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.01.114"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720030701"},{"key":"e_1_2_9_11_1","first-page":"9","article-title":"Neuroendocrine, immune, and local responses related to temporomandibular disorders","volume":"15","author":"Kopp S.","year":"2001","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22635"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21771"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.04.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.05.005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(97)00055-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.02.057"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3699"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00598.2009"}],"container-title":["Clinical and Experimental Dental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cre2.606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cre2.606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T06:59:55Z","timestamp":1692601195000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cre2.606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/cre2.606"],"URL":"https:\/\/doi.org\/10.1002\/cre2.606","archive":["Portico"],"relation":{},"ISSN":["2057-4347","2057-4347"],"issn-type":[{"value":"2057-4347","type":"print"},{"value":"2057-4347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"assertion":[{"value":"2021-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}