{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:20:43Z","timestamp":1759483243139,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical &amp; Exp Dental Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Oral rehabilitation can be a challenge in patients on high\u2010dose antiresorptive medication (HDAR), especially if the alveolar anatomy has changed due to previous medication\u2010related osteonecrosis of the jaw (MRONJ) resection. In healthy patients, dental implant treatment has found wide acceptance in prosthetic rehabilitation as it increases the patient's oral health\u2010related quality of life. However, it is considered contraindicated in patients on HDAR due to the risk of MRONJ, although a recent feasibility study indicates that implant treatment may indeed be an option in these patients. The aim of the present case report is to illustrate the risk of MRONJ in a patient with cancer on HDAR and to discuss the reasons behind the outcomes of the implant treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A patient with prostate cancer with bone metastases on high\u2010dose denosumab therapy with previous MRONJ had four implants inserted bilaterally in the maxilla (14, 13, 23, 24). Two identical implant\u2010supported screw\u2010retained cantilever bridges were fabricated. The patient was followed for more than 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Peri\u2010implantitis, and\/or MRONJ, was diagnosed around two of the implants (23, 24), probably induced by crestal bone trauma from a healing abutment and\/or a misfitting prosthetic reconstruction. A peri\u2010implantitis operation was performed, but without the desired response, and the two implants (23, 24) were later removed in an MRONJ resection. The implants on the other side of the maxilla (14, 13) remained without complications. Dental implant treatment is feasible in patients on HDAR, but comorbidities (e.g., diabetes mellitus) and polypharmacy (e.g., chemotherapy and steroids) may add to the risk of implant failure. Minimal trauma surgery and prosthodontics are crucial to increase the chance of successful healing in an HDAR patient.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cre2.620","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T13:46:09Z","timestamp":1658929569000},"page":"1059-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Medication\u2010related osteonecrosis of the jaw and successful implant treatment in a patient on high\u2010dose antiresorptive medication: A case report"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-8672","authenticated-orcid":false,"given":"Camilla","family":"Ottesen","sequence":"first","affiliation":[{"name":"School of Dentistry, Section for Oral Health, Society and Technology, Institute of Odontology, Research Area Oral Rehabilitation, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne W.\u00a0M.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Section for Oral Biology and Immunopathology, Institute of Odontology, Research Area Oral Surgery, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kofod","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Gotfredsen","sequence":"additional","affiliation":[{"name":"School of Dentistry, Section for Oral Health, Society and Technology, Institute of Odontology, Research Area Oral Rehabilitation, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116168"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","unstructured":"Andersen S. 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